WHAT IS ALREADY KNOWN ABOUT THIS TOPIC?: Human papillomavirus (HPV) is a globally prevalent sexually transmitted infection, with multiple genotypes strongly associated with cancers and other diseases. While extensive epidemiological data exist for HPV in females, studies on HPV genotype distribution in males, particularly those with confirmed HPV exposure, remain limited.

WHAT IS ADDED BY THIS REPORT?: This study provides a comprehensive analysis of HPV genotype distribution and its association with clinical outcomes in males with confirmed HPV exposure. The results demonstrate that low-risk HPV genotypes predominate in this population, with certain diseases showing unique HPV genotype associations. Additionally, older males exhibited a greater tendency toward multiple genotype co-infections.

WHAT ARE THE IMPLICATIONS FOR PUBLIC HEALTH PRACTICE?: This study underscores the importance of including males in HPV vaccination programs. Expanding vaccination coverage to males, combined with early screening and targeted public health education, can effectively reduce HPV transmission between sexes and decrease the overall burden of HPV-related diseases.