母亲哮喘与后代自闭症谱系障碍/注意力缺陷多动障碍之间的关联：一项基于观察性研究的荟萃分析

Association between maternal asthma and ASD/ADHD in offspring: A meta-analysis based on observational studies.

作者信息

Zheng Jingfang, Chen Junyi, Zhang Qiufeng, Ying Liying, Huang Hui, Yang Jingyu, Chen Zhenghao

机构信息

Department of Obstetrics and Gynaecology, The Affiliated People's Hospital of Ningbo University, 251 Baizhang East Road, Yinzhou District, Ningbo, 315040, Zhejiang, China.

The Second School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.

出版信息

NPJ Prim Care Respir Med. 2025 Jul 8;35(1):32. doi: 10.1038/s41533-025-00440-y.

DOI:10.1038/s41533-025-00440-y

PMID:40624093

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12234711/

Abstract

This meta-analysis aims to examine the association between maternal asthma and autism spectrum disorder (ASD) or attention deficit hyperactivity disorder (ADHD) in offspring. A literature search was performed in PubMed, Web of Science, Embase, and the Cochrane Library from electronic database inception to October 2024 for studies on the relationship between asthma and ASD/ADHD. The definition of maternal asthma was "asthma existing prior to childbirth". The primary outcome was the incidence of ASD/ADHD in the offspring. This meta-analysis incorporated 5 cohort studies and 7 case-control studies. The statistical results suggested that there is a higher incidence of ASD (odds ratio (OR) = 1.36, 95% confidence interval (95%CI) = 1.28-1.44, P < 0.001) and ADHD (OR = 1.43, 95% CI = 1.37-1.51, P < 0.001) in offspring with maternal asthma compared to the control group. The subgroup analysis revealed that there was no difference in ASD incidence between maternal asthma group and control group in subgroup of female (OR = 1.81, 95%CI = 0.72-4.25, P = 0.205). However, in subgroup of male, the incidence of ASD was higher in the maternal asthma group than the control group (OR = 1.28, 95%CI = 1.01-1.61, P = 0.04). Furthermore, an elevated incidence of ADHD was observed in the maternal asthma group compared to the control group, both in male offspring (OR = 1.36, 95%CI = 1.30-1.42, P < 0.001) and female offspring (OR = 1.45, 95%CI = 1.38-1.53, P < 0.001) subgroups. This study indicates that maternal asthma may have a potential association with ASD and ADHD in the offspring.

摘要

这项荟萃分析旨在研究母亲哮喘与后代自闭症谱系障碍（ASD）或注意力缺陷多动障碍（ADHD）之间的关联。从电子数据库建立至2024年10月，在PubMed、科学网、Embase和考科蓝图书馆中进行了文献检索，以查找关于哮喘与ASD/ADHD关系的研究。母亲哮喘的定义为“分娩前存在的哮喘”。主要结局是后代中ASD/ADHD的发病率。该荟萃分析纳入了5项队列研究和7项病例对照研究。统计结果表明，与对照组相比，母亲患有哮喘的后代中ASD（优势比（OR）=1.36，95%置信区间（95%CI）=1.28 - 1.44，P<0.001）和ADHD（OR = 1.43，95%CI = 1.37 - 1.51，P<0.0憨01）的发病率更高。亚组分析显示，在女性亚组中，母亲哮喘组和对照组之间的ASD发病率没有差异（OR = 1.81，95%CI = 0.72 - 4.25，P = 0.205）。然而，在男性亚组中，母亲哮喘组的ASD发病率高于对照组（OR = 1.憨八，95%CI = 1.01 - 1.61，P = 0.04）。此外，与对照组相比，母亲哮喘组中ADHD的发病率升高，在男性后代（OR = 1.36，95%CI = 1.30 - 1.42，P<0.001）和女性后代（OR = 1.45，95%CI = 1.38 - 1.53，P<0.001）亚组中均如此。本研究表明，母亲哮喘可能与后代的ASD和ADHD存在潜在关联。