桂哌齐特对犬缺血性心肌酸中毒的影响。

Effect of cinpropazide on ischemic myocardial acidosis in dogs.

作者信息

Sakai K, Haga N, Fujisawa Y, Abiko Y

出版信息

Arch Int Pharmacodyn Ther. 1985 Sep;277(1):83-91.

Abstract

In dogs anesthetized with pentobarbital, the left anterior descending coronary artery (LAD) was occluded by an occluder so that the LAD flow could be set to about half the original flow (partial occlusion). Partial occlusion of the LAD continued for 90 min, and myocardial pH decreased by 0.71 pH unit 30 min after the start of partial occlusion. Cinpropazide, a coronary vasodilator, was injected intravenously 30 min after partial occlusion. Cinpropazide at the dose of 1 mg/kg, which increased LAD flow insignificantly in the nonischemic normal heart, attenuated the myocardial pH that has been reduced by partial occlusion, with a slight reduction in diastolic blood pressure. Restoration of myocardial [H+] 60 min after the injection of cinpropazide was 75.3%, and that of saline solution was 29.5%, indicating that cinpropazide restored the myocardial [H+] by 45.8% during ischemia. The effect of cinpropazide to increase myocardial pH was not observed in the dog with nonischemic heart, however. It is concluded that cinpropazide attenuates myocardial acidosis during ischemia.

摘要

在戊巴比妥麻醉的犬中，用封堵器阻塞左冠状动脉前降支（LAD），使LAD血流设定为约为原来血流的一半（部分阻塞）。LAD部分阻塞持续90分钟，部分阻塞开始30分钟后心肌pH值下降0.71个pH单位。在部分阻塞30分钟后静脉注射冠状动脉血管扩张剂辛丙嗪。剂量为1mg/kg的辛丙嗪在非缺血正常心脏中对LAD血流增加不显著，但能减轻部分阻塞所致的心肌pH值降低，舒张压略有下降。注射辛丙嗪60分钟后心肌[H⁺]恢复率为75.3%，注射生理盐水的恢复率为29.5%，表明辛丙嗪在缺血期间使心肌[H⁺]恢复了45.8%。然而，在非缺血心脏的犬中未观察到辛丙嗪增加心肌pH值的作用。结论是辛丙嗪可减轻缺血期间的心肌酸中毒。