一例继发于爱泼斯坦-巴尔病毒感染的自发性脾破裂:病例报告
A spontaneous splenic rupture secondary to Epstein Barr Virus infection: a case report.
作者信息
Munzi Giulia, Casella Mariolo James Rossario, Poillucci Gaetano, Iodice Alessandra, Rossi Laura, Serao Angelo
机构信息
Department of General and Emergency Surgery, Ospedale dei Castelli (NOC), ASL Roma 6, Rome, Italy.
Department of General and Emergency Surgery, Ospedale dei Castelli (NOC), ASL Roma 6, Rome, Italy.
出版信息
Int J Surg Case Rep. 2025 Aug;133:111609. doi: 10.1016/j.ijscr.2025.111609. Epub 2025 Jul 2.
INTRODUCTION
Atraumatic Splenic Rupture (ASR) is a very rare and potentially life-threatening event associated with Epstein Barr Virus (EBV)-induced mononucleosis; it occurs in <0.5% of overall cases. The aim of the present study was to publish a case report of the ASR and to present a mini review of the international literature.
CASE PRESENTATION
A 22-year-old female presented to emergency department with abdominal pain, nausea and vomiting. The patient's medical history was unremarkable, and she denied trauma. On arrival, her vital signs were stable. However, laboratory examinations showed haemoglobin values of 7.8 g/dl, lymphocytosis and elevated liver function tests. Abdomen Computed Tomography (CT) scan highlighted haemoperitoneum and splenic hematoma. Angiography and embolization of active bleeding followed by emergency laparoscopic splenectomy were performed.
DISCUSSION
In patients without a history of trauma, spontaneous splenic rupture should be considered in the differential diagnosis if patients have abdominal and left shoulder tip pain, and laboratory results indicate low haemoglobin level. There is no consensus on treatment management on ASR.
CONCLUSION
This case underlines the importance of considering splenic rupture as a complication of EBV infection. Moreover, endovascular techniques and laparoscopic management can be considered to ensure a minimally invasive approach and improve outcomes.
引言
非创伤性脾破裂(ASR)是一种与爱泼斯坦-巴尔病毒(EBV)引起的单核细胞增多症相关的非常罕见且可能危及生命的事件;在所有病例中发生率低于0.5%。本研究的目的是发表一例ASR病例报告并对国际文献进行简要综述。
病例介绍
一名22岁女性因腹痛、恶心和呕吐就诊于急诊科。患者既往病史无异常,否认有外伤史。入院时,她的生命体征稳定。然而,实验室检查显示血红蛋白值为7.8g/dl,淋巴细胞增多,肝功能检查结果升高。腹部计算机断层扫描(CT)显示腹腔积血和脾血肿。随后进行了血管造影和对活动性出血的栓塞,接着进行了急诊腹腔镜脾切除术。
讨论
对于无外伤史的患者,如果出现腹痛和左肩尖疼痛,且实验室检查结果显示血红蛋白水平低,则在鉴别诊断中应考虑自发性脾破裂。关于ASR的治疗管理尚无共识。
结论
本病例强调了将脾破裂视为EBV感染并发症的重要性。此外,可以考虑采用血管内技术和腹腔镜管理以确保微创方法并改善治疗效果。
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本文引用的文献
Curr Pediatr Rev. 2024
Gastroenterol Res Pract. 2019-1-28
World J Emerg Surg. 2017-8-18
BMJ. 2014-4-2