Chakraborty Pallab, Pal Subharthi, Galstyan David S, Petersen Elena V, Amstislavskaya Tamara G, Kolesnikova Tatiana O, de Abreu Murilo S, Kalueff Allan V
Faculty of Biology, University of Freiburg, Freiburg, Germany.
Department of Zoology, Bhairab Ganguly College, Belgharia, Kolkata, West Bengal, India.
J Ayurveda Integr Med. 2025 Jul 7;16(4):101169. doi: 10.1016/j.jaim.2025.101169.
Traditional Indian medicine (Ayurveda) has a long history of treating central nervous system (CNS) disorders. Ayurvedic plants are typically rich in flavonoids, lignans, sterols, tannins and alkaloids that exert potent anti-inflammatory, anti-oxidant, neuroprotective and neurotropic effects in both humans and rodents. The zebrafish (Danio rerio) has emerged as a useful model species and a powerful vertebrate in vivo system for CNS disease modeling and drug screening. As zebrafish continue to demonstrate their growing utility for studying a wide range of pharmaceutical therapies, including Chinese and American traditional medicines, here we discuss CNS effects of various Ayurvedic medicinal plants, and how they can be further elucidated using zebrafish models. We also evaluate the existing challenges and limitations of using zebrafish models for studying Ayurvedic pharmacotherapy, as well as outline future directions of translational research in this field.
传统印度医学（阿育吠陀医学）在治疗中枢神经系统（CNS）疾病方面有着悠久的历史。阿育吠陀植物通常富含黄酮类化合物、木脂素、甾醇、单宁和生物碱，这些物质在人类和啮齿动物中均具有强大的抗炎、抗氧化、神经保护和向神经作用。斑马鱼（Danio rerio）已成为一种有用的模式物种和强大的脊椎动物体内系统，用于中枢神经系统疾病建模和药物筛选。随着斑马鱼在研究包括中美传统药物在内的广泛药物疗法方面的效用不断增加，在此我们讨论各种阿育吠陀药用植物对中枢神经系统的影响，以及如何使用斑马鱼模型进一步阐明这些影响。我们还评估了使用斑马鱼模型研究阿育吠陀药物疗法目前存在的挑战和局限性，并概述了该领域转化研究的未来方向。
