[在小鼠的H-2系统中用同种异体脾细胞免疫诱导T抑制细胞]

[Induction of T-suppressor cells by immunization with allogenic spleen cells in the H-2 system of mice].

作者信息

Karaulov A V, Abronina I F, Brondz B D

出版信息

Biull Eksp Biol Med. 1979 Oct;88(10):429-31.

PMID:40632

Abstract

The nature of suppressor cells induced by immunization with the allogenic spleen cells and inhibiting the DNA synthesis activation in the mixed lymphocyte culture was studied. Suppressor cells are resistant to mitomycin C and carrageenan. They are not inactivated by the treatment with rabbit anti-B- and anti-Ig- as well as with mouse antibodies (anti-Mls serum) against B lymphocytes in the presence of complement but eliminated by rabbit anti-lymphocyte and anti-T globulins and by mouse anti-theta serum. These T suppressor cells are concentrated in the large lymphocyte fraction in the ficoll gradient. Their blocking of the DNA synthesis activation is evidently non-specific.

摘要

研究了用同种异体脾细胞免疫诱导产生并抑制混合淋巴细胞培养中DNA合成激活的抑制细胞的性质。抑制细胞对丝裂霉素C和角叉菜胶有抗性。它们不会因用兔抗B和抗Ig以及在补体存在下用小鼠抗B淋巴细胞抗体（抗Mls血清）处理而失活，但会被兔抗淋巴细胞和抗T球蛋白以及小鼠抗θ血清消除。这些T抑制细胞集中在ficoll梯度中的大淋巴细胞部分。它们对DNA合成激活的阻断显然是非特异性的。

相似文献

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