Sun Ziyu, Zhu Kairui, Zhao Wenxuan, Fei Xi-Feng, Shi Lei, Zhang Yong
Department of Neurosurgery, The First People's Hospital of Kunshan, Gusu School, Nanjing Medical University, Suzhou, China.
Department of Neurosurgery and Nursing, Affiliated Kunshan Hospital to Jiangsu University, Suzhou, China.
Front Neurol. 2025 Jun 25;16:1594874. doi: 10.3389/fneur.2025.1594874. eCollection 2025.
Static magnetic field (SMF) therapy, a non-ionizing and non-invasive treatment modality, has garnered increasing attention in glioma research. Gliomas, particularly glioblastoma (GBM), represent one of the most aggressive malignancies of the central nervous system, with limited therapeutic options and significant treatment-related toxicity. Emerging evidence suggests that SMF therapy exerts antitumor effects by inducing apoptosis, inhibiting cell proliferation, and modulating the tumor microenvironment, while minimizing damage to surrounding healthy tissues. Despite promising preclinical findings, research on SMF therapy remains in its early stages, and its precise mechanisms, clinical efficacy, and safety require further elucidation. This review summarizes current advancements in SMF therapy for gliomas, explores its potential as a standalone or adjunctive treatment, and discusses future research directions to optimize its therapeutic application.
静磁场（SMF）疗法是一种非电离、非侵入性的治疗方式，在胶质瘤研究中受到越来越多的关注。胶质瘤，尤其是胶质母细胞瘤（GBM），是中枢神经系统中最具侵袭性的恶性肿瘤之一，治疗选择有限且存在显著的治疗相关毒性。新出现的证据表明，SMF疗法通过诱导细胞凋亡、抑制细胞增殖和调节肿瘤微环境发挥抗肿瘤作用，同时将对周围健康组织的损伤降至最低。尽管临床前研究结果很有前景，但SMF疗法的研究仍处于早期阶段，其确切机制、临床疗效和安全性需要进一步阐明。本综述总结了SMF疗法治疗胶质瘤的当前进展，探讨了其作为单一或辅助治疗的潜力，并讨论了优化其治疗应用的未来研究方向。
