糜烂性脓疱性皮肤病与阿美替尼治疗肺癌：一例报告
Erosive Pustular Dermatosis and Amivantamab for Lung Cancer: A Case Report.
作者信息
Senterre Yseult, Bouillenne Amandine, Sabatiello Murielle, Demoulin Anne-Sophie, Nikkels Arjen F
机构信息
Department of Dermatology, CHU University Hospital, Liège, Belgium.
Dermatology, Hôpital de la Citadelle, Liège, Belgium.
出版信息
Case Rep Dermatol. 2025 Jun 13;17(1):263-267. doi: 10.1159/000546616. eCollection 2025 Jan-Dec.
INTRODUCTION
Amivantamab is a monoclonal antibody against EGFR and MET receptors, indications for certain types of non-small cell lung cancer. Due to its mechanisms, cutaneous adverse effects are frequent and numerous.
CASE PRESENTATION
A 67-year-old woman with metastatic adenosquamous carcinoma, stage T3N2M1c, was treated with amivantamab after the first-line chemotherapy failed. Despite prophylactic oral tetracyclines, she developed severe erosive pustular dermatosis (EPD) affecting more than 50% of her scalp, forcing to cut short her hair to provide adequate local care.
CONCLUSION
EPD is an exceptional and severe adverse event of amivantamab, requiring oral steroids, tetracyclines and appropriate local care with antibiotic creams. Clinicians should be aware of this complication as early therapeutic intervention is mandatory to avoid deleterious consequences and spontaneous recurrences.
引言
阿米万他单抗是一种针对表皮生长因子受体（EGFR）和间充质上皮转化因子（MET）受体的单克隆抗体，适用于某些类型的非小细胞肺癌。因其作用机制，皮肤不良反应频繁且多样。
病例报告
一名67岁患有转移性腺鳞癌（T3N2M1c期）的女性在一线化疗失败后接受了阿米万他单抗治疗。尽管预防性口服了四环素，但她仍出现了严重的糜烂性脓疱性皮炎（EPD），头皮受累面积超过50%，不得不剪短头发以便进行充分的局部护理。
结论
EPD是阿米万他单抗一种罕见且严重的不良事件，需要口服类固醇、四环素以及使用抗生素乳膏进行适当的局部护理。临床医生应意识到这种并发症，因为早期治疗干预对于避免有害后果和自发复发是必不可少的。
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