Bittaye Sheikh Omar, Kambi Abubacarr, Tekanyi Momodou A I, Tamba Saydiba, Bojang Lamin, Sanneh Lamin, Sisawo Momodou Musa, Jatta Abdoulie, Fatty Gibril, Jeng Adam, Jallow Momodou Salieu, Leigh Ousman, Njie Ramou
Department of Internal Medicine Edward Francis Small Teaching Hospital Banjul The Gambia.
School of Medicine and Allied Health Sciences University of The Gambia Banjul The Gambia.
Health Sci Rep. 2025 Jul 9;8(7):e71006. doi: 10.1002/hsr2.71006. eCollection 2025 Jul.
BACKGROUND: HIV-hepatitis B co-infection rapidly progresses to fibrosis, cirrhosis, and HCC and has a poor prognosis. The study therefore assesses the prevalence of HIV and HIV-hepatitis B co-infection in the Gambia. METHODS: From June 2012 to September 2019, patients with confirmed diagnosis of HCC were enrolled. All patients medical history, ultrasound scan, fibroscan and laboratory details were collected. RESULTS: The study recruited 476 HCC patients. The prevalence of HIV amongst the HCC patient was 21 (4.4%), and this was higher in males, 19 (4.9%), than in females, 2 (2.2%). The HCC patients with Hepatitis B only were 319 (67.2%). Those HCC patients with HIV-hepatitis B co-infection were 17 (3.6%). HCC patients with HIV-hepatitis B co-infection were much younger and more likely to be male as compared to HCC patients with Hepatitis B only or HCC patients with negative HIV-hepatitis B. There was no difference between the median survivals of the three HCC patient groups. CONCLUSIONS: The prevalence of HIV in HCC patients is higher than in the general population. HIV-hepatitis B disproportionately affects young men, but there was no difference in survival. This study therefore confirms the need to have an integrated HIV-hepatitis B services in Hepatology clinics or screening programs in the Gambia to early detect co-infections, especially in young men and start them on treatment to prevent chronic liver disease complications and improve prognosis.
背景：HIV与乙肝合并感染会迅速发展为肝纤维化、肝硬化和肝癌，预后较差。因此，本研究评估了冈比亚HIV及HIV与乙肝合并感染的患病率。 方法：2012年6月至2019年9月，纳入确诊为肝癌的患者。收集所有患者的病史、超声扫描、肝脏硬度值测定及实验室检查细节。 结果：本研究招募了476例肝癌患者。肝癌患者中HIV的患病率为21例（4.4%），男性患病率更高，为19例（4.9%），女性为2例（2.2%）。仅患有乙肝的肝癌患者有319例（67.2%）。HIV与乙肝合并感染的肝癌患者有17例（3.6%）。与仅患有乙肝的肝癌患者或HIV与乙肝检测均为阴性的肝癌患者相比，HIV与乙肝合并感染的肝癌患者更年轻，且更可能为男性。三组肝癌患者的中位生存期无差异。 结论：肝癌患者中HIV的患病率高于普通人群。HIV与乙肝合并感染对年轻男性的影响尤为严重，但生存期无差异。因此，本研究证实冈比亚的肝病诊所或筛查项目需要提供HIV与乙肝综合服务，以便早期发现合并感染，尤其是在年轻男性中，并开始对他们进行治疗，以预防慢性肝病并发症并改善预后。
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