非人类灵长类动物中混合淋巴细胞反应与皮肤移植排斥反应的相关性

Correlation of mixed lymphocyte reactivity and skin graft rejection in nonhuman primates.

作者信息

Steele R W, Eichberg J W, Heberling R L, Kalter S S, Kniker W T

出版信息

J Med Primatol. 1977;6(2):119-26. doi: 10.1159/000459731.

Abstract

One-way mixed lymphocyte culture (MLC) reactivity and skin graft rejection were investigated to assess immune competence and histocompatibility in the baboon, the cebus monkey, and the cotton-topped marmoset. Adequate and comparable cell-mediated immunity was demonstrated. MLN reactions revealed strong histocompatibility differences among the three primate species and stimulating alloantigens for unrelated individuals of each species. Xenogeneic skin grafts survived nine days and allogeneic grafts, an average of 11 days. These systems appear readily applicable for assessing histocompatibility in nonhuman primates.

摘要

研究单向混合淋巴细胞培养（MLC）反应性和皮肤移植排斥反应，以评估狒狒、僧帽猴和棉顶狨猴的免疫能力和组织相容性。结果显示了充分且可比的细胞介导免疫。MLN反应揭示了这三种灵长类动物之间存在强烈的组织相容性差异，并为每个物种的无关个体刺激了同种异体抗原。异种皮肤移植存活了9天，同种异体移植平均存活11天。这些系统似乎很容易用于评估非人灵长类动物的组织相容性。