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儿科医生需要了解的关于膀胱输尿管反流现代泌尿外科管理的知识。

What paediatricians need to know about modern urologic management of vesicoureteral reflux.

作者信息

Goulin Jeanne, Demède Delphine, Ranchin Bruno, Mosca Mélodie, De-Mul Aurélie, Bidault Jourdainne Valeska

机构信息

Department of Pediatric Urovisceral, Thoracic and Transplantation Surgery, HFME, Civil Hospices of Lyon, Lyon, France.

MARVU Reference Center for Rare Congenital Malformations of Urinary Tract, Lyon, France.

出版信息

Front Pediatr. 2025 Jun 26;13:1607019. doi: 10.3389/fped.2025.1607019. eCollection 2025.

Abstract

Vesicoureteral reflux (VUR) is a common urological disorder in children, and its prevalence is difficult to determine, as many VUR cases remain asymptomatic. VUR is considered nearly physiological during infancy and often resolves spontaneously within the first few years of life. Most patients present with low-grade VUR, which is thought to be caused by an insufficient intramural course of the ureter in the bladder wall, a condition that tends to improve as the child grows and develops. The higher the grade of VUR , the lower the probability of spontaneous resolution of this condition during early childhood. Knowledge of the pathophysiology of VUR and renal scarring has evolved over the past decades. While surgical correction of VUR is thus often discussed, it is ultimately reserved for very selected cases, mainly when high-grade VUR persists despite the correction of voiding disorders in toilet-trained children and is associated with recurrent febrile UTI. European and other international pediatric urology societies have published guidelines for VUR management in children. With minimally invasive surgery becoming increasingly common among pediatric urologists, treatment modalities for VUR have evolved significantly, and endoscopic, laparoscopic, and robotic-assisted procedures now play a central role in surgical management. The recently updated ESPU/EAU guidelines are considered as a reference for pediatric urologists across Europe. In this review, we examine the recent literature and these guidelines to provide pediatricians with up-to-date data on VUR pathophysiology, its renal consequences, and current approaches to urological management.

摘要

膀胱输尿管反流(VUR)是儿童常见的泌尿系统疾病,由于许多VUR病例无症状,其患病率难以确定。VUR在婴儿期被认为近乎生理性,且常在生命的最初几年内自发缓解。大多数患者表现为低度VUR,这被认为是由于输尿管在膀胱壁内走行不足所致,这种情况往往随着儿童的生长发育而改善。VUR分级越高,幼儿期这种情况自发缓解的可能性越低。在过去几十年里,对VUR和肾瘢痕形成的病理生理学的认识不断发展。因此,虽然经常讨论VUR的手术矫正,但最终仅适用于非常特定的病例,主要是在如厕训练儿童的排尿障碍得到纠正后仍存在高度VUR且与复发性发热性尿路感染相关的情况。欧洲和其他国际小儿泌尿外科学会已发布儿童VUR管理指南。随着微创手术在小儿泌尿外科医生中越来越普遍,VUR的治疗方式有了显著发展,内镜、腹腔镜和机器人辅助手术现在在手术管理中发挥着核心作用。最近更新的ESPU/EAU指南被视为欧洲小儿泌尿外科医生的参考依据。在本综述中,我们研究了近期文献和这些指南,为儿科医生提供有关VUR病理生理学、其肾脏后果以及当前泌尿外科管理方法的最新数据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bb7/12241063/327e8797dc32/fped-13-1607019-g001.jpg

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