Cho Eunhan, Chodzko Miranda, Compton Stephanie L E, Yang Shengping, Heymsfield Steven, Spielmann Guillaume, Brown Justin C
Department of Kinesiology, LSU School of Kinesiology, Baton Rouge, LA, United States.
Department of Population and Public Health Science, Pennington Biomedical Research Center, Baton Rouge, LA, United States.
Front Sports Act Living. 2025 Jun 26;7:1579221. doi: 10.3389/fspor.2025.1579221. eCollection 2025.
Physical activity improves immune competency and is associated with a lower rate of cancer recurrence in colorectal cancer survivors. However, the exact mechanisms underlying these improvements remain unclear. Exercise-derived cytokines (exerkines), particularly IL-7 and IL-15, are crucial in maintaining optimal immune health. This study investigated whether a 12-week structured exercise training intervention increases IL-7 and IL-15 in colorectal cancer survivors.
Sixty colorectal cancer survivors were randomized to a moderate-intensity home-based aerobic exercise group (150 min/week) or a control group for 12 weeks. IL-7 and IL-15 were quantified using ELISA, and body composition was measured using dual-energy x-ray absorptiometry.
At baseline, participants treated with chemotherapy had lower IL-7 than those not treated with chemotherapy [-3.3 pg/ml (95% CI: -1.3, -5.4); = 0.002]. Baseline fitness capacity correlated with IL-15 ( = -0.37; = 0.004). IL-7 increased in the exercise group [2.3 pg/ml (95% CI: 0.9, 3.8; = 0.003)], but not in the control group [1.2 pg/ml (95% CI: 0.3, 2.8; = 0.31)]. IL-15 did not differ between groups. Longitudinal changes in IL-15 were associated with changes in body composition.
Aerobic exercise may improve immune function in colorectal cancer survivors by restoring IL-7 after chemotherapy and improving IL-15 by altering body composition.
[https://clinicaltrials.gov/study/NCT03975491], identifier [NCT03975491].
体育活动可提高免疫能力，并与结直肠癌幸存者较低的癌症复发率相关。然而，这些改善背后的确切机制仍不清楚。运动衍生细胞因子（运动因子），尤其是白细胞介素-7（IL-7）和白细胞介素-15（IL-15），对维持最佳免疫健康至关重要。本研究调查了为期12周的结构化运动训练干预是否会增加结直肠癌幸存者体内的IL-7和IL-15。
60名结直肠癌幸存者被随机分为中等强度居家有氧运动组（每周150分钟）或对照组，为期12周。使用酶联免疫吸附测定法（ELISA）对IL-7和IL-15进行定量，并使用双能X线吸收法测量身体成分。
在基线时，接受化疗的参与者的IL-7低于未接受化疗的参与者[-3.3皮克/毫升（95%置信区间：-1.3，-5.4）；P = 0.002]。基线体能与IL-15相关（P = -0.37；P = 0.004）。运动组的IL-7增加[2.3皮克/毫升（95%置信区间：0.9，3.8；P = 0.003）]，而对照组未增加[1.2皮克/毫升（95%置信区间：0.3，2.8；P = 0.31）]。两组之间的IL-15没有差异。IL-15的纵向变化与身体成分的变化相关。
有氧运动可能通过化疗后恢复IL-7以及通过改变身体成分改善IL-15来提高结直肠癌幸存者的免疫功能。
[https://clinicaltrials.gov/study/NCT03975491]，标识符[NCT03975491]。
