Masuda Soichiro, Fukasawa Toshiki, Otsuki Bungo, Murata Koichi, Shimizu Takayoshi, Sono Takashi, Honda Shintaro, Shima Koichiro, Sakamoto Masaki, Matsuda Shuichi, Kawakami Koji
Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Department of Pharmacoepidemiology.
Clin Spine Surg. 2025 Jul 11. doi: 10.1097/BSD.0000000000001876.
Cohort study.
To compare reoperation rates between anterior decompression and fusion (ADF) and posterior decompression and fusion (PDF) in patients with cervical ossification of the posterior longitudinal ligament (OPLL).
Reoperation after cervical OPLL surgery is a significant concern for both patients and surgeons. It is unclear which surgical approach, ADF or PDF, is superior in terms of reoperation rates for cervical OPLL.
This study was conducted under a cohort design in patients who underwent ADF or PDF for cervical OPLL using claims-based data. Primary outcome was the incidence of reoperation during the follow-up period, and secondary outcome was total health care costs during hospitalization, and at 30 days and 1 year postoperatively. Confounding factors were adjusted using propensity score inverse probability of treatment weighting. Cumulative incidence of reoperation was calculated using the Kaplan-Meier method. Hazard ratios (HRs) and 95% CIs were estimated using Cox proportional hazards regression models.
The study included 251 patients (123 patients in the ADF group and 128 in the PDF group). There was no significant difference in the incidence of reoperation between the 2 groups [weighted HR 2.00 (95% CI 0.76-5.25); P=0.16]. ADF was associated with lower mean costs than PDF during hospitalization [$6416 (95% CI $4898-$7,934); P <0.001], and at 30 days [$6449 (95% CI $4942-$7956)] and 1 year postoperatively [$10,268 ($6545-$13,992); P <0.001].
Although reoperation rates for ADF and PDF in patients with cervical OPLL were similar, ADF was associated with lower health care costs. This study provides important information that will help surgeons make informed decisions about the choice of surgical approach for patients with cervical OPLL.
队列研究。
比较颈椎后纵韧带骨化症(OPLL)患者前路减压融合术(ADF)与后路减压融合术(PDF)的再次手术率。
颈椎OPLL手术后的再次手术是患者和外科医生都非常关注的问题。目前尚不清楚在颈椎OPLL的再次手术率方面,哪种手术方式(ADF或PDF)更具优势。
本研究采用队列设计,利用基于索赔的数据对接受ADF或PDF治疗颈椎OPLL的患者进行研究。主要结局是随访期间再次手术的发生率,次要结局是住院期间、术后30天和1年的总医疗费用。使用倾向评分逆概率治疗加权法对混杂因素进行调整。采用Kaplan-Meier法计算再次手术的累积发生率。使用Cox比例风险回归模型估计风险比(HRs)和95%置信区间(CIs)。
该研究纳入了251例患者(ADF组123例,PDF组128例)。两组再次手术发生率无显著差异[加权HR 2.00(95% CI 0.76 - 5.25);P = 0.16]。ADF组住院期间的平均费用低于PDF组[$6416(95% CI $4898 - $7934);P < 0.001],术后30天[$6449(95% CI $4942 - $7956)]和术后1年[$10268($6545 - $13992);P < 0.