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气候变化与微生物转变:揭示癌症进展的潜在风险

Climate Change and the Microbial Shift: Unveiling Hidden Risks for Cancer Progression.

作者信息

Gopalakrishnan Vinoj, Saravanan Vaijayanthi, Mahendran Maria Infant Majula Shifani, Boopathy Vinoth, Vaithianathan Rajan, Srinivasan Sowmya

机构信息

MGM Advanced Research Institute, Sri Balaji Vidyapeeth (Deemed to be University), Pondicherry, India.

Vinoth Gastro Liver Clinic, Cuddalore, India.

出版信息

Cancer Epidemiol Biomarkers Prev. 2025 Sep 2;34(9):1448-1458. doi: 10.1158/1055-9965.EPI-25-0565.

Abstract

Climate change can lead to constant dysbiosis of the human microbiota, disrupting the delicate balance essential for maintaining good health. Climate change and its associated health risks are a growing area of research, yet its impact on human health, particularly for cancer patients and their relationship with microbes, remains largely unclear. While much attention is given to the effects of climate change on flora and fauna, its influence on microbes-both within the human body and in the environment deserves greater focus. Climate shifts can lead to constant dysbiosis of the human microbiota, disrupting the delicate balance, essential for maintaining good health. This interplay between host and environmental microbes is crucial for a healthy life. As climate change accelerates, it creates a favourable niche for pathogens, often exacerbated by antimicrobial resistance. Cancer patients, already immunocompromised, may be especially vulnerable to these microbial fluctuations driven by changing climates. Our review explores the existing studies that link climate change with microbial disturbances and how these shifts may contribute to cancer progression and accompanied comorbidities. Future research is essential to unravel the connection between climate change, microbial dysbiosis, and cancer development, shedding light on an often-overlooked threat to human health.

摘要

气候变化可导致人类微生物群持续失调,破坏维持良好健康所必需的微妙平衡。气候变化及其相关的健康风险是一个不断发展的研究领域,然而其对人类健康的影响,尤其是对癌症患者的影响以及他们与微生物的关系,在很大程度上仍不清楚。虽然人们对气候变化对动植物的影响给予了很多关注,但其对人体内外微生物的影响值得更多关注。气候转变可导致人类微生物群持续失调,破坏维持良好健康所必需的微妙平衡。宿主与环境微生物之间的这种相互作用对健康生活至关重要。随着气候变化加速,它为病原体创造了有利的生态位,抗菌药物耐药性往往会加剧这种情况。已经免疫功能低下的癌症患者可能特别容易受到气候变化驱动的这些微生物波动的影响。我们的综述探讨了将气候变化与微生物干扰联系起来的现有研究,以及这些变化如何可能促进癌症进展和伴随的合并症。未来的研究对于揭示气候变化、微生物失调和癌症发展之间的联系至关重要,从而揭示对人类健康这一经常被忽视的威胁。

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