Comparison of 18F-NOTA-NFB and 11C-Methionine PET/MRI in Detecting Glioma Recurrence.

A 37-year-old woman with recurrent glioblastoma in the right temporo-occipital lobe after surgery exhibited contrast-enhanced foci on contrast-enhanced MRI, with mild tracer uptake on 11C-methionine PET/MRI and significantly increased tracer uptake on 18F-NOTA-NFB, an 18F-labeled chemokine receptor-4-targeted PET tracer, PET/MRI. 18F-NOTA-NFB PET showed a significantly higher tumor-to-background ratio for recurrence than 11C-methionine PET, allowing a more precise visualization of recurrent lesions. This case indicates that 18F-NOTA-NFB PET/MRI might give advantages in glioma delineation that might provide valuable information for making a treatment strategy and personalized radiotherapy planning.