Surono Ingrid S, Venema Koen, Martosudarmo Subijanto, Kusumo Pratiwi D
Food Technology Department, Faculty of Engineering, Bina Nusantara University, Jakarta 11480, Indonesia.
Centre for Healthy Eating & Food Innovation, Maastricht University, Campus Venlo, 5928 SZ Venlo, The Netherlands.
Foods. 2025 Jun 24;14(13):2218. doi: 10.3390/foods14132218.
We have previously shown a difference between the gut microbiota composition of stunted and non-stunted children in East Nusa Tenggara, Indonesia. The current study aimed to perform an intervention with a probiotic, IS-10506, and its UHT-treated postbiotic compared to placebo in order to accomplish catch-up growth in the stunted children, possibly through modulation of the gut microbiota. Apart from the maltodextrin (placebo), probiotic, and postbiotic in chocolate milk, all groups also received a functional and nutritional biscuit and had access to newly constructed water wells as well as soap to improve hygiene. The results show that independent of treatment, the stunted children had a significantly higher increase in height and zlen (corrected for age) compared with their age- and gender-matched controls but a significantly lower increase in weight. Several potential pathogenic taxa declined in all groups, among which was / (adjusted. = 6.44 × 10), but so did some beneficial taxa, such as and . , which was already higher in the stunted children at baseline, increased independent of treatment. Changes in the relative abundance of several taxa of the microbiota correlated with the changes in anthropometric measures. In conclusion, although there was no difference between the interventions, understanding the dynamics and the role of the gut microbiota in this process might allow healthcare providers to develop targeted nutritional strategies aimed at optimizing health outcomes for children at risk of stunting, thereby addressing a critical global health issue.
我们之前已经表明，印度尼西亚东努沙登加拉发育迟缓儿童与非发育迟缓儿童的肠道微生物群组成存在差异。本研究旨在使用益生菌IS-10506及其超高温处理后生元与安慰剂进行干预，以便发育迟缓儿童实现追赶生长，这可能是通过调节肠道微生物群来实现的。除了巧克力牛奶中的麦芽糊精（安慰剂）、益生菌和后生元外，所有组还接受了功能性营养饼干，并可以使用新建的水井和肥皂以改善卫生状况。结果表明，无论治疗如何，与年龄和性别匹配的对照组相比，发育迟缓儿童的身高和身长（校正年龄）显著增加，但体重增加显著较低。所有组中几种潜在致病类群减少，其中/（调整后 = 6.44×10），但一些有益类群也减少了，如和。在基线时发育迟缓儿童中已经较高的，在不考虑治疗的情况下增加了。微生物群的几个类群的相对丰度变化与人体测量指标的变化相关。总之，虽然干预措施之间没有差异，但了解肠道微生物群在此过程中的动态和作用可能会使医疗保健提供者制定有针对性的营养策略，旨在优化发育迟缓风险儿童的健康结果，从而解决一个关键的全球健康问题。
