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伴有同步锁骨上转移的乳腺癌患者的锁骨上淋巴结清扫术：一项系统评价和网状Meta分析

Supraclavicular Lymph Node Dissection in Breast Cancer with Synchronous Supraclavicular Metastases: A Systematic Review and Network Meta-Analysis.

作者信息

He George Shiyao, Chia Jolene Li Ling, Santos Emmeline Elaine Cua-De Los, Chew Wong Hung, Koh Wee Yao, Ng Qin Xiang, Ow Samuel, Goh Serene Si Ning

机构信息

NUS Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119077, Singapore.

Department of Surgery, National University Hospital, Singapore 119074, Singapore.

出版信息

Cancers (Basel). 2025 Jun 21;17(13):2081. doi: 10.3390/cancers17132081.

DOI:10.3390/cancers17132081
PMID:40647382
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12248947/
Abstract

BACKGROUND/OBJECTIVES: Synchronous ipsilateral supraclavicular lymph node metastases (sISLMs) in breast cancer are rare and associated with poor prognosis. The optimal locoregional treatment strategy remains unclear, particularly regarding the role of supraclavicular lymph node dissection (SLND).

METHODS

We conducted a systematic review and network meta-analysis, including studies published up to end December 2023, to compare the outcomes of SLND combined with radiotherapy (RT) and systemic therapy (ST), SLND with ST alone, and ST alone, using RT + ST as the reference.

RESULTS

Ten studies involving 3346 patients were included for overall survival (OS) analysis, and six studies were included for disease-free survival (DFS). SLND + RT + ST showed similar OS and DFS compared to RT + ST. Sensitivity analyses revealed that SLND limited to level V improved OS (HR: 0.47, 95% CI: 0.29-0.77), while more extensive dissections (level V+) worsened outcomes (HR: 1.41, 95% CI: 1.10-1.80).

CONCLUSIONS

These findings suggest that selective SLND may benefit certain patients, but broader application should be approached with caution pending results from future randomized trials.

摘要

背景/目的：乳腺癌同侧锁骨上淋巴结同步转移（sISLMs）较为罕见，且与预后不良相关。最佳的局部区域治疗策略仍不明确，尤其是关于锁骨上淋巴结清扫术（SLND）的作用。

方法

我们进行了一项系统评价和网状Meta分析，纳入截至2023年12月底发表的研究，以比较SLND联合放疗（RT）和全身治疗（ST）、单纯SLND联合ST以及单纯ST的疗效，以RT + ST作为对照。

结果

纳入10项涉及3346例患者的研究进行总生存期（OS）分析，6项研究进行无病生存期（DFS）分析。与RT + ST相比，SLND + RT + ST的OS和DFS相似。敏感性分析显示，局限于Ⅴ级的SLND可改善OS（HR：0.47，95%CI：0.29 - 0.77），而更广泛的清扫（Ⅴ级以上）则使预后恶化（HR：1.41，95%CI：1.10 - 1.80）。

结论

这些结果表明，选择性SLND可能使某些患者受益，但在未来随机试验结果出来之前，应谨慎考虑更广泛的应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bc8/12248947/2bad59c2e5c8/cancers-17-02081-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bc8/12248947/5467529b911f/cancers-17-02081-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bc8/12248947/9fe6318f3f13/cancers-17-02081-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bc8/12248947/d73a04d9aded/cancers-17-02081-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bc8/12248947/31c22244be12/cancers-17-02081-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bc8/12248947/bbbde4fbc69c/cancers-17-02081-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bc8/12248947/da10872b58f7/cancers-17-02081-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bc8/12248947/2bad59c2e5c8/cancers-17-02081-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bc8/12248947/5467529b911f/cancers-17-02081-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bc8/12248947/9fe6318f3f13/cancers-17-02081-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bc8/12248947/d73a04d9aded/cancers-17-02081-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bc8/12248947/31c22244be12/cancers-17-02081-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bc8/12248947/bbbde4fbc69c/cancers-17-02081-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bc8/12248947/da10872b58f7/cancers-17-02081-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bc8/12248947/2bad59c2e5c8/cancers-17-02081-g007.jpg

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本文引用的文献

1
Harnessing Artificial Intelligence to Enhance Global Breast Cancer Care: A Scoping Review of Applications, Outcomes, and Challenges.利用人工智能提升全球乳腺癌护理水平：应用、成果及挑战的范围综述
Cancers (Basel). 2025 Jan 9;17(2):197. doi: 10.3390/cancers17020197.
2
Adjuvant medial versus entire supraclavicular lymph node irradiation in high-risk early breast cancer (SUCLANODE): a protocol for a multicenter, randomized, open-label, phase 3 trial.高危早期乳腺癌（SUCLANODE）中辅助内上与全锁骨上区域淋巴结照射对比的多中心、随机、开放标签、3 期临床试验方案。
BMC Cancer. 2024 Jan 9;24(1):49. doi: 10.1186/s12885-024-11831-8.
3
Role of aggressive locoregional surgery in treatment strategies for ipsilateral supraclavicular lymph node metastasis of breast cancer: a real-world cohort study.
积极的局部区域手术在乳腺癌同侧锁骨上淋巴结转移治疗策略中的作用：一项真实世界队列研究
Front Mol Biosci. 2023 Oct 17;10:1248410. doi: 10.3389/fmolb.2023.1248410. eCollection 2023.
4
Brachial plexopathy after breast cancer: A persistent late effect of radiotherapy.乳腺癌后的臂丛神经病：放疗的持续性迟发效应。
PM R. 2024 Jan;16(1):85-91. doi: 10.1002/pmrj.13007. Epub 2023 Jul 31.
5
Comparison of supraclavicular surgery plus radiotherapy versus radiotherapy alone in breast cancer patients with synchronous ipsilateral supraclavicular lymph node metastasis: A multicenter retrospective study.锁骨上手术联合放疗与单纯放疗治疗同侧锁骨上淋巴结转移乳腺癌患者的比较：一项多中心回顾性研究。
Radiother Oncol. 2023 Jun;183:109639. doi: 10.1016/j.radonc.2023.109639. Epub 2023 Mar 27.
6
Long-term Oncologic Outcomes in Patients with Inflammatory Breast Cancer with Supraclavicular Nodal Involvement.锁骨上淋巴结受累炎性乳腺癌患者的长期肿瘤学结局。
Ann Surg Oncol. 2022 Oct;29(10):6381-6392. doi: 10.1245/s10434-022-12144-5. Epub 2022 Jul 14.
7
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J Natl Compr Canc Netw. 2022 Jun;20(6):691-722. doi: 10.6004/jnccn.2022.0030.
8
The role of surgery on locoregional treatment of patients with breast cancer newly diagnosed with ipsilateral supraclavicular lymph node metastasis.手术在新诊断为同侧锁骨上淋巴结转移的乳腺癌患者局部区域治疗中的作用。
J Cancer Res Ther. 2022 Apr;18(2):496-502. doi: 10.4103/jcrt.jcrt_844_21.
9
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Cancers (Basel). 2021 Dec 29;14(1):164. doi: 10.3390/cancers14010164.
10
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Int J Radiat Oncol Biol Phys. 2022 Jan 1;112(1):66-74. doi: 10.1016/j.ijrobp.2021.08.026. Epub 2021 Oct 25.