Prodan-Bărbulescu Cătălin, Faur Flaviu Ionuț, Varga Norberth-Istvan, Hajjar Rami, Pașca Paul, Ghenciu Laura-Andreea, Feier Cătălin Ionuț Vlăduț, Dema Alis, Fărcuț Naomi, Bolintineanu Sorin, Dobrescu Amadeus, Duță Ciprian, Brebu Dan
Department I, Discipline of Anatomy and Embriology, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania.
2nd Surgery Clinic, Timisoara Emergency County Hospital, 300723 Timisoara, Romania.
Cancers (Basel). 2025 Jul 2;17(13):2219. doi: 10.3390/cancers17132219.
Gastric neoplasms remain pathologies of the malignant spectrum with high incidence and prevalence, with their management requiring a precise histopathological characterization for optimal treatment planning. The present study is a retrospective analysis that included 67 histopathologically confirmed gastric neoplasia subjects and was performed at a single surgical center from January 2020 to December 2021. Demographics, tumor characteristics, surgical procedures, and oncologic outcomes were included, filtered, and subsequently analyzed using SPSS Statistics 29.0. : This study involved 67 patients (mean age 65.7 years, 56.7% men), with adenocarcinoma being the most common histologic type (91.0%) and most tumors being diagnosed directly as Stage III (40.3%). Lauren classification revealed the intestinal type as the most common (49.2%), followed by diffuse (36.1%) and mixed (14.8%). Poorly differentiated tumors (G3) accounted for 53.7% of cases. The surgical team performed curative resection in 75% (n = 50) of patients, achieving R0 margins in 88% of these cases. Subtotal gastrectomy with D2 lymphadenectomy yielded the highest curative success rate with 96.6% R0 resection. Statistically, we identified two significant correlations between age and tumor grade (rho = 0.28; = 0.021) and between the number of lymph nodes examined and the number of lymph nodes invaded (rho = 0.65, < 0.001). This study again revealed that adenocarcinomas showed higher rates of lymph node invasion than other tumor types ( = 0.017). : The analysis of patients with gastric neoplasms is vital for appropriate therapeutic management. Even though the study period included a pandemic, the analysis remained a complex one with high-quality surgical outcomes, confirming the importance of maintaining oncologic standards during medical crises.
胃肿瘤仍然是恶性疾病谱中的高发病率和高患病率病症，其治疗需要精确的组织病理学特征来制定最佳治疗方案。本研究是一项回顾性分析，纳入了67例经组织病理学确诊的胃肿瘤患者，研究于2020年1月至2021年12月在单一外科中心进行。纳入了人口统计学、肿瘤特征、手术方式和肿瘤学结局等信息，进行筛选后，使用SPSS Statistics 29.0进行分析。本研究涉及67例患者（平均年龄65.7岁，男性占56.7%），腺癌是最常见的组织学类型（91.0%），大多数肿瘤直接诊断为III期（40.3%）。劳伦分类显示肠型最为常见（49.2%），其次是弥漫型（36.1%）和混合型（14.8%）。低分化肿瘤（G3）占病例的53.7%。手术团队对75%（n = 50）的患者进行了根治性切除，其中88%的病例实现了R0切缘。D2淋巴结清扫的胃次全切除术的根治成功率最高，R0切除率为96.6%。从统计学角度，我们发现年龄与肿瘤分级之间存在两个显著相关性（rho = 0.28；P = 0.021），以及检查的淋巴结数量与侵袭的淋巴结数量之间存在显著相关性（rho = 0.65，P < 0.001）。本研究再次表明，腺癌的淋巴结侵袭率高于其他肿瘤类型（P = 0.017）。对胃肿瘤患者的分析对于恰当的治疗管理至关重要。尽管研究期间包括一场大流行，但该分析仍是一项具有高质量手术结局的复杂分析，证实了在医疗危机期间维持肿瘤学标准的重要性。
