Derkaczew Maria, Zglejc-Waszak Kamila, Dabrowski Lukasz, Kocik Janusz, Zdaniukiewicz Adam, Thoene Michael, Jozwik Marcin, Gonkowski Slawomir, Wojtkiewicz Joanna
Students' Scientific Club of Pathophysiologists, Department of Human Physiology and Pathophysiology, School of Medicine, University of Warmia and Mazury in Olsztyn, 10-082 Olsztyn, Poland.
Department of Anatomy and Histology, School of Medicine, Collegium Medicum, University of Warmia and Mazury in Olsztyn, 10-082 Olsztyn, Poland.
J Clin Med. 2025 Jul 3;14(13):4706. doi: 10.3390/jcm14134706.
: Bisphenol A (BPA) is an organic compound used in producing polycarbonates and epoxy resins found in products such as food containers, disposable bottles, CDs, and DVDs. Its structure resembles that of endogenous estrogen, which classifies BPA as an endocrine-disrupting chemical (EDC). BPA has been associated with various health abnormalities, including cancer and reproductive system cancer. In this study, we examine the association between BPA exposure, BPA levels in blood serum, and the occurrence of breast cancer and reproductive system cancer. : A total of 84 females were included in this cross-sectional study. All participants completed a questionnaire assessing BPA exposure and underwent a blood test to measure BPA levels in serum. : Analysis of the lifestyle questionnaire revealed behavioral differences potentially associated with BPA exposure. A statistically significant difference was observed for responses to Question 13, related to food preparation methods, while responses to Questions 5, 6, and 17 showed trends approaching statistical significance in cancer groups. Serum BPA concentrations were significantly higher in patients with reproductive system cancer compared to the control group ( = 0.045), while a non-significant trend was observed between breast cancer patients and patients with reproductive system cancer ( = 0.0884). : In summary, our study demonstrated significantly elevated serum BPA levels in patients with reproductive system cancer compared to controls. These results suggest the hypothesis that higher exposure to BPA may influence or be associated with the development of estrogen-dependent cancers such as breast and endometrial cancer. However, due to the cross-sectional design of the study, causality cannot be established, and further longitudinal studies are warranted.
双酚A（BPA）是一种有机化合物，用于生产聚碳酸酯和环氧树脂，存在于食品容器、一次性瓶子、CD和DVD等产品中。其结构类似于内源性雌激素，这将双酚A归类为内分泌干扰化学物质（EDC）。双酚A与各种健康异常有关，包括癌症和生殖系统癌症。在本研究中，我们研究了双酚A暴露、血清中双酚A水平与乳腺癌和生殖系统癌症发生之间的关联。
本横断面研究共纳入84名女性。所有参与者都完成了一份评估双酚A暴露的问卷，并接受了血液检测以测量血清中的双酚A水平。
对生活方式问卷的分析揭示了可能与双酚A暴露相关的行为差异。对于与食物制备方法相关的问题13的回答，观察到有统计学显著差异，而癌症组对问题5、6和17的回答显示出接近统计学显著的趋势。与对照组相比，生殖系统癌症患者的血清双酚A浓度显著更高（P = 0.045），而乳腺癌患者与生殖系统癌症患者之间观察到无显著趋势（P = 0.0884）。
总之，我们的研究表明，与对照组相比，生殖系统癌症患者的血清双酚A水平显著升高。这些结果提出了一个假设，即更高的双酚A暴露可能影响或与雌激素依赖性癌症如乳腺癌和子宫内膜癌的发生有关。然而，由于本研究的横断面设计，无法确定因果关系，因此有必要进行进一步的纵向研究。
