Li Xuedong, Xu Mingli, Wang Yingying
Department of Immunology, School of Basic Medical Sciences, Chongqing Medical University, Chongqing 400016, China.
Chongqing Key Laboratory of Basic and Translational Research of Tumor Immunology, Chongqing Medical University, Chongqing 400016, China.
Int J Mol Sci. 2025 Jul 3;26(13):6422. doi: 10.3390/ijms26136422.
Classical BCR-ABL-negative myeloproliferative neoplasms are a heterogeneous group of hematologic malignancies, including essential thrombocythemia, polycythemia vera, and primary myelofibrosis. Monocytes, immune cells derived from hematopoietic stem cells, exhibit significant heterogeneity and contribute to immune regulation through cytokine secretion and differentiation into dendritic cells and macrophages. Aberrant monocytes are associated with the prognosis of MPNs, particularly PMF. Furthermore, these altered monocytes play a critical role in the pathogenesis and progression of MPNs. This review aims to explore the heterogeneity of different monocyte subsets during homeostasis and focuses on the potential mechanisms by which monocytes contribute to the development and progression of MPNs.
经典的BCR-ABL阴性骨髓增殖性肿瘤是一组异质性血液系统恶性肿瘤，包括原发性血小板增多症、真性红细胞增多症和原发性骨髓纤维化。单核细胞是源自造血干细胞的免疫细胞，具有显著的异质性，并通过细胞因子分泌以及分化为树突状细胞和巨噬细胞来参与免疫调节。异常单核细胞与骨髓增殖性肿瘤的预后相关，尤其是原发性骨髓纤维化。此外，这些改变的单核细胞在骨髓增殖性肿瘤的发病机制和进展中起关键作用。本综述旨在探讨稳态期间不同单核细胞亚群的异质性，并着重研究单核细胞促进骨髓增殖性肿瘤发生和发展的潜在机制。
