Malnutrition-induced changes of responses evoked in the rat prefrontal cortex as revealed by sensitivity to strychnine.

Susceptibility to strychnine of somatosensory responses evoked in the prefrontal cortex was studied in normal and protein-malnourished rats in three groups. (a) The normal group was from mothers fed a 21% casein diet. (b) The prenatally malnourished group was from mothers fed a 6% casein diet during 5 weeks prior to mating and throughout gestation. (c) The postnatally malnourished group born from dams fed a 6% casein diet throughout the nursing period. At 45 days of age, sensitivity of the responses to 0.5% strychnine sulfate solution was tested by measuring changes in peak-to-peak amplitude. The results showed that cortical neurons of the postnatally protein-restricted group had decreased susceptibility to strychnine, indicating functional disturbances of glycinergic synapses.