尼泊尔三级儿科医院收治的依赖输血的β地中海贫血儿童维生素D缺乏情况：一项描述性横断面研究
Vitamin D Deficiency among Blood Transfusion Dependent Beta Thalassemia Children Admitted to Tertiary Level Pediatric Hospital in Nepal: A Descriptive Cross-sectional Study.
作者信息
Shrestha Anil Kumar, Sherpa Sangay Chultim, Gyawali Bindu, Sharma Manisha, Adhikari Santosh, Shrestha Suchitra, Bhattarai Susan, Thapa Sagar, Sharma Devashish, Paudel Prajwal, Gyawali Sushil
机构信息
Department of Pediatrics, Kanti Children's Hospital, Maharajgunj, Kathmandu, Nepal.
Department of Medicine, Om Hospital and Research Center, Chabahil, Kathmandu, Nepal.
出版信息
JNMA J Nepal Med Assoc. 2024 Oct;62(278):621-626. doi: 10.31729/jnma.8779. Epub 2024 Oct 31.
INTRODUCTION
Children with beta thalassemia are on regular blood transfusions, which could result in iron deposition in the liver causing decreased synthesis of Vitamin D-25OH. There are limited publications on the association of Vitamin D deficiency with blood transfusion-dependent thalassemia in the Nepalese population. This study aims to determine the prevalence of Vitamin D deficiency among blood transfusion-dependent beta-thalassemia patients.
METHODS
This was a descriptive cross-sectional study conducted among beta-thalassemia major patients under 15 years of age, receiving regular blood transfusion, from July 17, 2022, to July 16, 2023, after attaining ethical approval from Ethical Review Committee, (reference number 155). Data were collected using convenience sampling, and descriptive analyses were performed using Microsoft Excel and Statistical Package for Social Sciences (SPSS) 2024.
RESULTS
A total of 127 blood transfusion-dependent beta-thalassemia major patients were included in the study, of whom 82 (64.56%) were female. Among these patients, 104 (81.88%) were aged between 5 and 14 year. Among 127, 41 (32.28%) had Vitamin D insufficiency, and 31 (24.40%) had Vitamin D deficiency. There were 12 (9.44%) underweight children.
CONCLUSIONS
Vitamin D deficiency was seen in more than half of the children with blood transfusion dependent beta thalassemia major.
引言
患有β地中海贫血的儿童需定期输血，这可能导致铁在肝脏中沉积，从而使维生素D-25OH的合成减少。关于尼泊尔人群中维生素D缺乏与输血依赖型地中海贫血之间关联的出版物有限。本研究旨在确定输血依赖型β地中海贫血患者中维生素D缺乏的患病率。
方法
这是一项描述性横断面研究，于2022年7月17日至2023年7月16日在15岁以下接受定期输血的重型β地中海贫血患者中进行，研究获得了伦理审查委员会的伦理批准（参考编号155）。数据采用便利抽样收集，并使用Microsoft Excel和社会科学统计软件包（SPSS）2024进行描述性分析。
结果
本研究共纳入127例输血依赖型重型β地中海贫血患者，其中82例（64.56%）为女性。在这些患者中，104例（81.88%）年龄在5至14岁之间。在127例患者中，41例（32.28%）存在维生素D不足，31例（24.40%）存在维生素D缺乏。有12例（9.44%）儿童体重过轻。
结论
在超过一半的输血依赖型重型β地中海贫血儿童中发现了维生素D缺乏。
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