Meharwal Meenal, Sarpal Rajeev, Agarwal Shikhar, Dhebane Meghali, Ray Jitendra Prasad, Dutta Rishin, Joshi Divyanshu
General Surgery, Swami Rama Himalayan University, Dehradun, IND.
Urology, Swami Rama Himalayan University, Dehradun, IND.
Cureus. 2025 Jun 12;17(6):e85863. doi: 10.7759/cureus.85863. eCollection 2025 Jun.
An interventional study was conducted in the Department of Urology at a tertiary care center in Dehradun, India, to assess the efficacy of tranexamic acid (TXA) in reducing blood loss during percutaneous nephrolithotomy (PCNL).
A total of 99 patients with renal calculi were recruited for this study over a period of 18 months. Subjects were selected from patients presenting with a history of flank pain in the Outpatient Department (OPD). Written informed consent for the inclusion of patient data in the study was obtained from all participants. The study was undertaken after obtaining ethical clearance from the Institutional Ethics Committee.
In this study, there was no statistical difference in gender between the groups receiving TXA and those not receiving it (p-value = 0.492). The mean age of the recruited cases in both groups was between 42 and 43 years. This study recorded calyceal puncture sites, irrigating fluid used, and pre- and postoperative hemoglobin and packed cell volume (PCV) values to calculate blood loss. Additionally, body mass index (BMI), co-morbidities, stone size, ease of puncture and dilatation, and operative time were recorded as other variables for both groups. There was no mortality observed in any of the patients postoperatively. Blood loss was much lower in patients receiving TXA.
TXA is safe and effective in reducing blood loss during PCNL.
在印度德拉敦一家三级医疗中心的泌尿外科进行了一项干预性研究，以评估氨甲环酸（TXA）在经皮肾镜取石术（PCNL）中减少失血的疗效。
在18个月的时间里，共招募了99例肾结石患者参与本研究。研究对象从门诊有腰痛病史的患者中选取。所有参与者均签署了将患者数据纳入研究的书面知情同意书。本研究在获得机构伦理委员会的伦理批准后开展。
在本研究中，接受TXA治疗的组与未接受TXA治疗的组在性别上无统计学差异（p值 = 0.492）。两组招募病例的平均年龄均在42至43岁之间。本研究记录了肾盏穿刺部位、使用的冲洗液以及术前和术后的血红蛋白和血细胞比容（PCV）值，以计算失血量。此外，还记录了两组的体重指数（BMI）、合并症、结石大小、穿刺和扩张的难易程度以及手术时间等其他变量。术后所有患者均未观察到死亡情况。接受TXA治疗的患者失血量明显更低。
TXA在减少PCNL术中失血方面安全有效。
