Samaan Farid, Clemente Áurea Maria Izabel, Zaicaner Raquel, Kirsztajn Gianna Mastroianni, Sesso Ricardo
Planning Group, State Department of Health of São Paulo, 351 Dr. Arnaldo Avenue, 5th Floor, São Paulo, SP, 01246-000, Brazil.
Research Division, Dante Pazzanese Institute of Cardiology, 500 Dr. Dante Pazzanese Avenue, São Paulo, SP, 04012-909, Brazil.
Int Urol Nephrol. 2025 Jul 14. doi: 10.1007/s11255-025-04652-6.
We aim to analyze the requests for the initiation of kidney replacement therapy (KRT) in the public health system of the state of São Paulo, Brazil.
Initial KRT requests sent to the Regulation Center of the State Department of Health between 01/01/2023 and 12/31/2024 were evaluated. KRT initiation was considered "planned" if it occurred outside the hospital environment or the patient started hemodialysis (HD) with an arteriovenous fistula (AVF).
A total of 8451 individuals from 17 healthcare macroregions were included [median interquartile range (IQR)] age: 62 (51-71) years; male sex: 60%; etiology of CKD: 57% hypertension and 21% diabetes). Conservative predialysis treatment of CKD was implemented for 26% of patients in the state, ranging from 4 to 44% in the macroregions. The percentage of patients initiating HD with AVF was 10% (variation in macroregions: 4-25%), and people who initiated KRT in hospital were 70% (37-94%). The initial modality was HD in 95% of the patients (range: 73-100%) (peritoneal dialysis in 5% [(0-27%)], and the median waiting time for a KRT slot vacancy was 12 (IQR: 6-29) days (1 (1-4) to 31 (14-75) in macroregions). Multiple regression analysis revealed that conservative treatment of CKD was independently associated with planned initiation of KRT (odds ratio [OR] [95% confidence interval (CI) = 4.99 (4.48-5.54); p < 0.001].
The results demonstrate the need to adopt actions to implement pre-dialysis care for people with CKD and to mitigate regional inequalities in access to chronic dialysis in this population.
我们旨在分析巴西圣保罗州公共卫生系统中启动肾脏替代治疗(KRT)的申请情况。
对2023年1月1日至2024年12月31日期间发送至州卫生部监管中心的首次KRT申请进行评估。如果KRT启动发生在医院环境之外,或者患者通过动静脉内瘘(AVF)开始血液透析(HD),则认为是“计划内”启动。
共纳入了来自17个医疗大区的8451名个体[年龄中位数(四分位间距)(IQR):62(51 - 71)岁;男性:60%;慢性肾脏病(CKD)病因:高血压57%,糖尿病21%]。该州26%的患者接受了CKD的保守透析前治疗,各医疗大区的比例在4%至44%之间。通过AVF开始HD的患者比例为10%(各医疗大区的变化范围:4% - 25%),在医院启动KRT的患者为70%(37% - 94%)。95%的患者初始治疗方式为HD(范围:73% - 100%)(5%为腹膜透析[(0 - 27%)]),KRT空位的中位等待时间为12(IQR:6 - 29)天(各医疗大区为1(1 - 4)至31(14 - 75)天)。多元回归分析显示,CKD的保守治疗与KRT的计划内启动独立相关(优势比[OR][95%置信区间(CI)= 4.99(4.48 - 5.54);p < 0.001])。
结果表明有必要采取行动,为CKD患者实施透析前护理,并减轻该人群在获得慢性透析方面的地区不平等现象。