Deng Tinghan, Wu Jingping, Cheng Hongbin
Clinical Research on Skin Diseases, School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine (TCM), Chengdu, Sichuan, China.
Department of Medical Cosmetology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Front Clin Diabetes Healthc. 2025 Jun 30;6:1590288. doi: 10.3389/fcdhc.2025.1590288. eCollection 2025.
This study examines the correlation between skin autofluorescence (SAF) and blood glucose levels, emphasizing the accumulation of advanced glycation end-products (AGEs). We hypothesize that SAF levels are closely linked to type 1 diabetes complications in children. The aim is to evaluate SAF's relationship with type 1 diabetes progression in children and its potential as a non-invasive tool for disease detection and monitoring complications. The research was registered with PROSPERO (CRD42021284774).
We conducted a meta-analysis by extracting studies from databases including PubMed, MEDLINE, EMBASE, Cochrane, Science Direct, Scopus, and Web of Science. A random effects model was used to assess if SAF measurement could serve as a non-invasive marker for type 1 diabetes and its complications. SAF values were compared between children with type 1 diabetes and controls, calculating the mean difference and 95% confidence intervals.
The analysis included three case-control studies and one retrospective cohort study, all using the AGE Reader (DiagnOptics Technologies). Data analysis showed significant heterogeneity (I² = 82%, P < 0.05). The random effects model revealed a positive correlation between higher SAF levels and type 1 diabetes in children [mean difference = 0.20 (0.16, 0.25)], indicating elevated SAF in diabetic children compared to non-diabetic peers.
This research supports SAF measurement as a non-invasive indicator for type 1 diabetes and its complications in children. However, further studies with larger samples and longer follow-up are needed for definitive conclusions and detailed insights into complications. Additionally, the skin's multifaceted roles require further investigation.
https://www.crd.york.ac.uk/prospero/, identifier CRD42021284774.
本研究探讨皮肤自发荧光（SAF）与血糖水平之间的相关性，重点关注晚期糖基化终末产物（AGEs）的积累。我们假设SAF水平与儿童1型糖尿病并发症密切相关。目的是评估SAF与儿童1型糖尿病进展的关系及其作为疾病检测和监测并发症的非侵入性工具的潜力。该研究已在国际前瞻性系统评价注册库（PROSPERO）注册（注册号：CRD42021284774）。
我们通过从包括PubMed、MEDLINE、EMBASE、Cochrane、Science Direct、Scopus和Web of Science在内的数据库中提取研究进行荟萃分析。使用随机效应模型评估SAF测量是否可作为1型糖尿病及其并发症的非侵入性标志物。比较1型糖尿病儿童和对照组的SAF值，计算平均差异和95%置信区间。
分析包括三项病例对照研究和一项回顾性队列研究，均使用AGE Reader（DiagnOptics Technologies）。数据分析显示存在显著异质性（I² = 82%，P < 0.05）。随机效应模型显示儿童中较高的SAF水平与1型糖尿病之间存在正相关[平均差异 = 0.20（0.16，0.25）]，表明糖尿病儿童的SAF高于非糖尿病同龄人。
本研究支持SAF测量作为儿童1型糖尿病及其并发症的非侵入性指标。然而，需要进一步开展更大样本量和更长随访时间的研究，以得出明确结论并深入了解并发症情况。此外，皮肤的多方面作用也需要进一步研究。
