柔红霉素的微生物转化为N-乙酰基-13(S)-二氢柔红霉素和双脱水-13-二氢柔红霉素酮。
Microbial conversion of daunorubicin into N-acetyl-13(S)-dihydrodaunomycin and bisanhydro-13-dihydrodaunomycinone.
作者信息
Dornberger K, Hübener R, Ihn W, Thrum H, Radics L
出版信息
J Antibiot (Tokyo). 1985 Sep;38(9):1219-25. doi: 10.7164/antibiotics.38.1219.
PMID:4066504
Abstract
By using a strain of Streptomyces willmorii, daunorubicin (daunomycin) was stereoselectively converted into N-acetyl-13(S)-dihydrodaunomycin and bisanhydro-13-dihydrodaunomycinone. The absolute stereochemistry of the new chiral center in N-acetyl-13(S)-dihydrodaunomycin was established by means of nuclear Overhauser effect measured in the 9,13-O-isopropylidene derivative.
摘要
通过使用一株威尔莫里链霉菌，柔红霉素（红比霉素）被立体选择性地转化为N-乙酰基-13(S)-二氢柔红霉素和双脱水-13-二氢柔红霉酮。在9,13-O-异亚丙基衍生物中通过核Overhauser效应确定了N-乙酰基-13(S)-二氢柔红霉素中新手性中心的绝对立体化学。
Zotero 插件