咖啡因会降低人脸识别记忆巩固的准确性。
Caffeine reduces accuracy in face recognition memory consolidation.
作者信息
Leon Candela S, Lo Celso Agustina L, Guajardo Rocío A, Forcato Cecilia
机构信息
Laboratorio de Sueño y Memoria, Departamento de Ciencias de la Vida, Instituto Tecnológico de Buenos Aires (ITBA), Iguazú 341, 1437, Buenos Aires, Argentina.
Consejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET), Buenos Aires, Argentina.
出版信息
Sci Rep. 2025 Jul 16;15(1):25722. doi: 10.1038/s41598-025-11737-w.
Numerous studies have shown that caffeine facilitates cognition, particularly memory, when consumed before learning and immediately tested. However, most of this evidence relates to its effects during encoding, and the role in memory consolidation remains unclear. A key study demonstrated that caffeine administered after learning can enhance object recognition memory consolidation by improving discrimination between previously seen targets and similar lures. Here, we investigated the effects of post encoding caffeine on the consolidation of face recognition memory using a randomized, double-blind design. Participants (N = 97) viewed ten generated faces on Day 1 and then received 200 mg of caffeine or placebo. On Day 2, they completed a recognition task under two conditions: Present condition (original face with five similar distractors) or Absent condition (six similar distractors) adding a "none of the above" option. The results showed that, contrary to our expectation, caffeine consumption did not improve the consolidation of face recognition memory. Instead, we observed a general impairment in recognition performance, suggesting a reduced ability to distinguish previously encountered from novel but similar faces. These findings discuss the idea of caffeine as a general cognition enhancer and aligned with studies suggesting it enhances global processing at the expense of detailed discrimination.
大量研究表明,在学习前摄入咖啡因并立即进行测试时,咖啡因有助于认知,尤其是记忆。然而,这些证据大多与它在编码过程中的作用有关,其在记忆巩固中的作用仍不明确。一项关键研究表明,学习后给予咖啡因可以通过改善对先前见过的目标与相似诱饵之间的辨别能力来增强物体识别记忆巩固。在此,我们采用随机双盲设计研究了编码后咖啡因对人脸识别记忆巩固的影响。参与者(N = 97)在第1天观看了10张合成面孔,然后服用200毫克咖啡因或安慰剂。在第2天,他们在两种条件下完成了一项识别任务:呈现条件(原始面孔与五个相似的干扰项)或缺失条件(六个相似的干扰项),并增加了一个“以上都不是”的选项。结果表明,与我们的预期相反,摄入咖啡因并没有改善人脸识别记忆的巩固。相反,我们观察到识别表现普遍受损,这表明区分先前遇到的面孔与新的但相似面孔的能力下降。这些发现讨论了咖啡因作为一种一般认知增强剂的观点,并与一些研究一致,这些研究表明它以牺牲详细辨别为代价增强整体加工。