Sawut Abdulla, Meng Yang, Lhamo Tsering, Xiao Di, Su Yu, Chen Changzheng
Eye Center, Renmin Hospital of Wuhan University, 99 Zhangzhidong Road, Wuhan, 430060, China.
BMC Ophthalmol. 2025 Jul 16;25(1):413. doi: 10.1186/s12886-025-04231-4.
Multiple evanescent white dot syndrome (MEWDS) is a rare transient inflammatory retinopathy characterized by discrete white dots disseminated on the fundus. Focal scleral nodule (FSN) typically presents as a stable, solitary, yellow-white, subretinal lesion arising from the sclera. This article reports a rare case of MEWDS associated with FSN in a young female.
A 34-year-old female presented with a complaint of gradually enlarging paracentral scotomas in the left eye for 8 days. At presentation, best-corrected visual acuity (BCVA) was 20/25 in the left eye. Fundus examination of the left eye revealed optic disc edema and an orange-yellow irregular lesion on the infratemporal side of the fovea. The multimodal imaging (MMI) findings revealed a rather typical MEWDS-like reaction and a subretinal lesion located at the sclera. After thorough consideration, the patient was diagnosed with MEWDS associated with FSN. Corticosteroid therapy was then administered to the patient. After 11 weeks, her BCVA recovered to 20/20 in the left eye, and the visual field defect had improved. Additionally, the MEWDS-like reaction had significantly recovered. The FSN remained stable during the 18-month follow-up.
This is the first reported case of MEWDS associated with FSN, expanding the understanding of both conditions.
多发性一过性白点综合征（MEWDS）是一种罕见的一过性炎症性视网膜病变，其特征为眼底出现散在的白色小点。局灶性巩膜结节（FSN）通常表现为一个稳定的、孤立的、黄白色的、源于巩膜的视网膜下病变。本文报告了一例年轻女性中罕见的MEWDS合并FSN的病例。
一名34岁女性因左眼中心旁暗点逐渐扩大8天前来就诊。就诊时，左眼最佳矫正视力（BCVA）为20/25。左眼眼底检查发现视盘水肿以及黄斑颞下侧有一个橙黄色不规则病变。多模式成像（MMI）结果显示出相当典型的类似MEWDS的反应以及一个位于巩膜的视网膜下病变。经过全面考虑，该患者被诊断为MEWDS合并FSN。随后对患者进行了皮质类固醇治疗。11周后，她的左眼BCVA恢复到20/20，视野缺损有所改善。此外，类似MEWDS的反应已显著恢复。在18个月的随访期间，FSN保持稳定。
这是首例报道的MEWDS合并FSN的病例，拓展了对这两种病症的认识。
