He Qiuping, Xie Lei, Peng Haining, Xiao Xiao, Yu Tengbo
Department of Orthopedic Surgery, Qingdao Municipal Hospital, Qingdao University, Qingdao, 266000, China.
Central Laboratories, Qingdao Municipal Hospital, University of Health and Rehabilitation Sciences, Qingdao, 266000, China.
Apoptosis. 2025 Jul 18. doi: 10.1007/s10495-025-02135-8.
Sodium sulfite (SS) is a common food additive that is widely absorbed and distributed throughout the body, but its excessive intake has been linked to adverse health effects. Here, we investigate the impact of chronic SS exposure on bone tissue and the underlying mechanisms. Using a mouse model, we demonstrate that prolonged SS exposure induces significant bone loss, which correlates with alterations in ferroptosis-related markers. In vitro, SS exposure activates ferroptosis, which is characterized by elevated reactive oxygen species levels and impaired osteogenic differentiation in MC3T3 cells. Notably, melatonin, a potent endogenous antioxidant, mitigates SS-induced oxidative stress, inhibits ferroptosis, restores osteoblast function, and alleviates bone loss in mice. These findings highlight ferroptosis as a critical contributor to SS-induced osteoporosis and identify melatonin as a promising therapeutic agent for its prevention and treatment.
亚硫酸钠（SS）是一种常见的食品添加剂，可被人体广泛吸收并分布于全身，但其过量摄入与不良健康影响有关。在此，我们研究慢性SS暴露对骨组织的影响及其潜在机制。使用小鼠模型，我们证明长期SS暴露会导致显著的骨质流失，这与铁死亡相关标志物的改变有关。在体外，SS暴露会激活铁死亡，其特征是活性氧水平升高以及MC3T3细胞中成骨分化受损。值得注意的是，褪黑素是一种强大的内源性抗氧化剂，可减轻SS诱导的氧化应激，抑制铁死亡，恢复成骨细胞功能，并减轻小鼠的骨质流失。这些发现突出了铁死亡是SS诱导的骨质疏松症的关键因素，并确定褪黑素是其预防和治疗的一种有前景的治疗剂。
