溃疡性血管瘤的非典型发育与快速消退：一例报告
Atypical development and swift resolution of an ulcerated hemangioma: a case report.
作者信息
Chakhunashvili Konstantine, Kvirkvelia Eka, Chakhunashvili Davit G
机构信息
Caucasus University, Tbilisi, Georgia.
Children's Clinic After I. Tsitsishvili, Tbilisi, Georgia.
出版信息
J Med Case Rep. 2025 Jul 18;19(1):352. doi: 10.1186/s13256-025-05422-9.
BACKGROUND
Infantile hemangiomas are considered as the most common benign vascular tumors in pediatric patients. Ulceration is one of the most frequent complications that typically occur at 2-3 months after birth.
CASE PRESENTATION
A Caucasian Georgian male infant started to develop a hemangioma at 5 days old. At 3 weeks old, a pediatrician diagnosed it, and the patient was referred to a dermatologist. A week after starting initial treatment, at 4 weeks of age, the hemangioma ulcerated. Despite changing the initial treatment, the ulceration worsened. At 6 weeks old, topical timolol and mupirocin were initiated, leading to complete healing within 4 weeks. Timolol is still being applied, and follow-up visits showed no further ulceration.
CONCLUSION
Although the exact cause of the unusual ulcer development is unknown, we advise physicians to avoid prescribing topical ointments that have not been proven effective and safe for treating hemangioma.
背景
婴儿血管瘤被认为是儿科患者中最常见的良性血管肿瘤。溃疡是最常见的并发症之一，通常在出生后2至3个月出现。
病例介绍
一名格鲁吉亚裔白种男婴在5日龄时开始出现血管瘤。3周龄时，一名儿科医生对其进行了诊断，该患者被转诊至皮肤科医生处。在开始初始治疗一周后，即4周龄时，血管瘤发生了溃疡。尽管改变了初始治疗方案，但溃疡仍恶化。6周龄时，开始使用局部噻吗洛尔和莫匹罗星，4周内实现了完全愈合。目前仍在使用噻吗洛尔，随访显示未再出现溃疡。
结论
尽管异常溃疡发展的确切原因尚不清楚，但我们建议医生避免开具未经证实对治疗血管瘤有效且安全的局部软膏。
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