Lee Seung Won, Kang Chaeyoon, Choi Unbi, Jung Hohyun, Bae Youngoh
Department of Precision Medicine, Sungkyunkwan University School of Medicine, Suwon 16419, Republic of Korea; Personalized Cancer Immunotherapy Research Center, Sungkyunkwan University School of Medicine, Suwon 16419, Republic of Korea; Department of Artificial Intelligence, Sungkyunkwan University, Suwon 16419, Republic of Korea; Department of Family Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 03181, Republic of Korea.
Sungkyunkwan University School of Medicine, Seoul 06355, Republic of Korea.
Epilepsy Behav. 2025 Oct;171:110602. doi: 10.1016/j.yebeh.2025.110602. Epub 2025 Jul 18.
To evaluate the long-term psychiatric consequences of an epilepsy diagnosis on the incidence of anxiety disorders among patients in South Korea.
This study utilized data from the Korean National Health Insurance Service spanning 2002-2013 to analyze longitudinal risks and contributing factors for anxiety disorders among 2109 patients with epilepsy compared to 21,090 matched controls.
Patients with epilepsy demonstrated a significantly higher risk of developing anxiety disorders, with an incidence rate of 65.38 per 1000 person-years (95 % CI, 59.61-71.28) versus 33.13 per 1000 person-years (95 % CI, 31.89-34.38) for controls. The incidence rate ratio (IRR) was 1.97 (95 % CI, 1.79-2.18), indicating nearly double the risk relative to the control group. This risk was particularly pronounced in males and individuals under 60, underscoring age and male sex as key risk factors for anxiety post-epilepsy diagnosis.
The findings underscore the critical need for prompt psychological evaluations and interventions in the management of epilepsy. Addressing these psychological impacts early can significantly enhance outcomes and quality of life for patients, particularly among those at greater risk such as males under the age of 60.
评估癫痫诊断对韩国患者焦虑症发病率的长期精神影响。
本研究利用韩国国民健康保险服务中心2002年至2013年的数据，分析2109例癫痫患者与21090例匹配对照者中焦虑症的纵向风险及相关因素。
癫痫患者发生焦虑症的风险显著更高，发病率为每1000人年65.38例（95%置信区间，59.61 - 71.28），而对照组为每1000人年33.13例（95%置信区间，31.89 - 34.38）。发病率比（IRR）为1.97（95%置信区间，1.79 - 2.18），表明相对于对照组，风险几乎翻倍。这种风险在男性和60岁以下个体中尤为明显，凸显年龄和男性性别是癫痫诊断后焦虑的关键风险因素。
研究结果强调了在癫痫管理中及时进行心理评估和干预的迫切需求。早期解决这些心理影响可显著改善患者的治疗效果和生活质量，尤其是在风险较高的人群中，如60岁以下的男性。
