Rodríguez-Domínguez Álvaro-José, Rebollo-Salas Manuel, Chillón-Martínez Raquel, Cardellat-González Melania, Blanco-Heras Laura, Jiménez-Rejano José-Jesús
Department of Health and Sports, Pablo de Olavide University, Seville, Spain.
Department of Physiotherapy, University of Seville, Seville, Spain.
Pain Res Manag. 2025 Jul 10;2025:7550108. doi: 10.1155/prm/7550108. eCollection 2025.
The objective was to compare the effectiveness of a combined pain neuroscience education and resistance training program (PNE + RT) with that of a combined aerobic and flexibility exercise program (AE + FE). A randomized pilot study was conducted in women with fibromyalgia. Thirty-one women with fibromyalgia were randomized into the experimental group (PNE + RT, = 15) and the usual care group (AE + FE, = 16). Both groups carried out the intervention 3 days a week for 12 weeks. Primary outcomes were pain intensity, disability, and symptoms related to central sensitization (CS). Among them, pain intensity was considered the main primary endpoint for statistical analysis and interpretation. Secondary outcomes were pressure pain threshold (PPT), maximum handgrip strength (MHS), and stiffness. Statistically significant between-group differences were found in favor of PNE + RT group for short-term pain intensity ( < 0.05) and PPT trapezius ( < 0.05). PNE + RT also showed statistically significant within-group improvements in pain intensity ( < 0.01), CS-related symptoms ( < 0.01), PPT quadriceps ( < 0.01), and MHS of the left hand ( < 0.01). Disability improved significantly in both groups ( < 0.01). There were no significant changes in stiffness. The PNE + RT program is more effective than the AE + FE program in improving pain intensity in the short term and PPT in the trapezius muscle in the long term. PNE + RT is also effective in improving disability, pain intensity, CS-related symptoms (short and long term), and left MHS and PPT in the quadriceps muscle (long term), although it is not more effective than AE + FE. The AE + FE program is only effective in improving disability. These findings are preliminary, and larger studies are needed to confirm the results. ClinicalTrials.gov identifier: NCT04855851.
目的是比较疼痛神经科学教育与抗阻训练相结合的方案（PNE+RT）和有氧运动与柔韧性训练相结合的方案（AE+FE）的效果。对患有纤维肌痛的女性进行了一项随机试点研究。31名纤维肌痛女性被随机分为实验组（PNE+RT，n=15）和常规护理组（AE+FE，n=16）。两组均每周进行3天干预，共12周。主要结局指标为疼痛强度、残疾情况以及与中枢敏化（CS）相关的症状。其中，疼痛强度被视为统计分析和解读的主要主要终点。次要结局指标为压痛阈值（PPT）、最大握力（MHS）和僵硬程度。在短期疼痛强度方面，发现PNE+RT组具有统计学显著的组间差异（P<0.05），斜方肌PPT方面也有显著差异（P<0.05）。PNE+RT在组内疼痛强度（P<0.01）、CS相关症状（P<0.01）、股四头肌PPT（P<0.01）和左手MHS（P<0.01）方面也显示出统计学显著改善。两组的残疾情况均有显著改善（P<0.01）。僵硬程度无显著变化。PNE+RT方案在短期内改善疼痛强度以及长期改善斜方肌PPT方面比AE+FE方案更有效。PNE+RT在改善残疾情况、疼痛强度、CS相关症状（短期和长期）以及股四头肌的左MHS和PPT（长期）方面也有效，尽管不比AE+FE更有效。AE+FE方案仅在改善残疾情况方面有效。这些发现是初步的，需要更大规模的研究来证实结果。ClinicalTrials.gov标识符：NCT04855851。
