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Superior performance of two combined polygenic scores for predicting skin cancer risk and differentiating risk of melanoma from keratinocyte carcinomas in two cohorts.

作者信息

Liu Luzheng, Tran Huy, Mulford Ashley J, Shi Zhuqing, Wei Jun, Ashworth Annabelle, Zheng S Lilly, Waldinger Jason B, Levy Ross M, Sanders Alan R, Xu Jianfeng

机构信息

Division of Dermatology, Endeavor Health, Evanston, Illinois.

University of Chicago Pritzker School of Medicine, Chicago, Illinois.

出版信息

JAAD Int. 2025 Jun 6;21:70-72. doi: 10.1016/j.jdin.2025.03.004. eCollection 2025 Aug.

Abstract
摘要

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本文引用的文献

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Integrative polygenic risk score improves the prediction accuracy of complex traits and diseases.
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2
Personalized medicine in a community health system: the NorthShore experience.
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3
Common Germline Risk Variants Impact Somatic Alterations and Clinical Features across Cancers.
Cancer Res. 2023 Jan 4;83(1):20-27. doi: 10.1158/0008-5472.CAN-22-1492.
4
The UK Biobank resource with deep phenotyping and genomic data.
Nature. 2018 Oct;562(7726):203-209. doi: 10.1038/s41586-018-0579-z. Epub 2018 Oct 10.
5
Familial Risk and Heritability of Cancer Among Twins in Nordic Countries.
JAMA. 2016 Jan 5;315(1):68-76. doi: 10.1001/jama.2015.17703.

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