Seidel H J, Kreja L
Nat Immun Cell Growth Regul. 1985;4(4):193-201.
BDF1 mice injected with methylnitrosourea (MNU, 50 mg/kg) developed T cell leukemias within 9-35 weeks (median induction time 18 weeks). Leukemic cells, determined by transplantation, were found 2-5 weeks before the death of the animals. Natural killer (NK) cell activity in the spleen and peritoneal exudate cells was studied using YAC-1 cells as targets. MNU-treated mice showed reduced lytic activity with or without stimulation by Corynebacterium parvum. NK activity was essentially the same in mice with and without transplantable leukemic cells. No correlation could be demonstrated between the degree of NK cell depression, as studied in the spleen after splenectomy, and the survival time of individual mice.
给BDF1小鼠注射甲基亚硝基脲（MNU，50毫克/千克）后，在9至35周内（中位诱导时间18周）发生了T细胞白血病。通过移植确定，在动物死亡前2至5周发现了白血病细胞。以YAC-1细胞为靶细胞，研究了脾脏和腹腔渗出细胞中的自然杀伤（NK）细胞活性。用或不用短小棒状杆菌刺激，MNU处理的小鼠均表现出溶解活性降低。有或没有可移植白血病细胞的小鼠的NK活性基本相同。脾切除术后在脾脏中研究的NK细胞抑制程度与个体小鼠的存活时间之间未显示出相关性。
