Wang Ke, Huang Guoxin, Liu Ying, Zhang Beibei, Qian Da, Pei Bin
Department of Burn and Plastic Surgery-Hand Surgery, Changshu Hospital Affiliated to Soochow University, Changshu No.1 People's Hospital, Changshu, China.
Department of Evidence-Based Medicine Center, Xiangyang No.1 People's Hospital, Hubei University of Medicine, Xiangyang, China.
J Nutr Sci. 2025 Jul 18;14:e51. doi: 10.1017/jns.2024.38. eCollection 2025.
Femoral neck bone mineral density (FNBMD) is a high risk factor for femoral head fractures, and coffee intake affects bone mineral density, but the effect on FNBMD remains to be explored. First, we conducted an observational study in the National Health and Nutrition Examination Survey and collected data on coffee intake, FNBMD, and sixteen covariates. Weight linear regression was used to explore the association of coffee intake with FNBMD. Then, Mendelian randomisation (MR) was used to explore the causal relationship between coffee intake and FNBMD, the exposure factor was coffee intake, and the outcome factor was FNBMD. The inverse variance weighting (IVW) method was used for the analysis, while heterogeneity tests, sensitivity, and pleiotropy analysis were performed. A total of 5 915 people were included in the cross-sectional study, including 3 178 men and 2 737 women. In the completely adjusted model, no coffee was used as a reference. The ORs for the overall population at '< 1', '1-<2', '2-<4', and '4+' (95% CI) were 0.02 (-0.01, 0.04), 0.00 (-0.01, 0.02), -0.01 (-0.02, 0.00), and 0.00 (-0.01, 0.02), respectively. The male and female population showed no statistically significant differences in both univariate and multivariate linear regressions. In the MR study, the IVW results showed an OR (95% CI) of 1.06 (0.88-1.27), a -value of 0.55, and an overall -value of 80.31. The heterogeneity, sensitivity analyses, and pleiotropy had no statistical significance. Our study used cross-sectional studies and MR to demonstrate that there is no correlation or causal relationship between coffee intake and FNBMD.
股骨颈骨密度（FNBMD）是股骨头骨折的一个高风险因素，而咖啡摄入量会影响骨密度，但对FNBMD的影响仍有待探索。首先，我们在美国国家健康与营养检查调查中进行了一项观察性研究，收集了关于咖啡摄入量、FNBMD和16个协变量的数据。采用加权线性回归来探讨咖啡摄入量与FNBMD之间的关联。然后，使用孟德尔随机化（MR）来探讨咖啡摄入量与FNBMD之间的因果关系，暴露因素为咖啡摄入量，结果因素为FNBMD。采用逆方差加权（IVW）方法进行分析，同时进行异质性检验、敏感性分析和多效性分析。横断面研究共纳入5915人，其中男性3178人，女性2737人。在完全调整模型中，以不喝咖啡作为参照。总体人群中，“<1杯”“1 - <2杯”“2 - <4杯”和“4杯及以上”（95%CI）的比值比分别为0.02（-0.01，0.04）、0.00（-0.01，0.02）、-0.01（-0.02，0.00）和0.00（-0.01，0.02）。在单变量和多变量线性回归中，男性和女性人群均未显示出统计学上的显著差异。在MR研究中，IVW结果显示比值比（95%CI）为1.06（0.88 - 1.27），P值为0.55，总体P值为80.31。异质性、敏感性分析和多效性均无统计学意义。我们的研究通过横断面研究和MR证明，咖啡摄入量与FNBMD之间不存在相关性或因果关系。
