Wang Yun, Cao Meng
Department of Pediatrics, Wuxi No. 2 People's Hospital, Wuxi, Jiangsu, China.
Department of Endocrinology, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan, China.
Front Pediatr. 2025 Jul 7;13:1624344. doi: 10.3389/fped.2025.1624344. eCollection 2025.
Attention-Deficit/Hyperactivity Disorder (ADHD) characterized by symptoms of inattention, hyperactivity, and impulsivity, with substantial impacts on a child's academic performance, social interactions, and overall quality of life. This study investigates the impact of combining a multi-micronutrient nutritional formula (MNF) with cognitive behavioral therapy (CBT) in managing ADHD symptoms in children.
In a retrospective analysis of 220 children aged 6-14 years diagnosed with ADHD, patients were divided into two groups: the MNF group ( = 112) receiving only the nutritional formula, and the MNF-CBT group ( = 108) receiving both the nutritional formula and CBT. The interventions were conducted over three months. Outcomes were measured using the Conners Parent Symptom Questionnaire (PSQ), SNAP-IV Teacher Form, and Dundee Difficult Times of the Day Scale (D-DTODS).
Both groups were comparable at baseline in terms of demographics and ADHD symptom severity. Post-treatment analyses revealed greater reductions in attention deficit scores, hyperactivity/impulsivity scores, and oppositional symptoms scores in the MNF-CBT group compared to the MNF group. Conduct scores were lower in the MNF-CBT group than in the MNF group, and learning scores also showed a similar pattern of reduction. Functional impairments across various daily activities, as measured by the D-DTODS, were also reduced in the MNF-CBT group. No adverse events or safety concerns were observed during the intervention period.
The combination of multi-micronutrient supplementation with CBT shows potential in alleviating both neurochemical deficiencies and behavioral dysregulation in children with ADHD. These findings suggest that this integrated approach may be beneficial for managing ADHD symptoms.
注意力缺陷多动障碍（ADHD）以注意力不集中、多动和冲动为特征，对儿童的学业成绩、社交互动和整体生活质量有重大影响。本研究调查了将多种微量营养素营养配方（MNF）与认知行为疗法（CBT）相结合对儿童ADHD症状状管理症状的影响。
在对220名6至14岁被诊断为ADHD的儿童进行的回顾性分析中，患者被分为两组：仅接受营养配方的MNF组（n = 112）和同时接受营养配方和CBT的MNF - CBT组（n = 108）。干预持续三个月。使用康纳斯父母症状问卷（PSQ）、SNAP - IV教师版和邓迪每日困难时段量表（D - DTODS）测量结果。
两组在人口统计学和ADHD症状严重程度方面基线可比。治疗后分析显示，与MNF组相比，MNF - CBT组的注意力缺陷得分、多动/冲动得分和对立症状得分降低幅度更大。MNF - CBT组的品行得分低于MNF组，学习得分也呈现类似的降低模式。根据D - DTODS测量，MNF - CBT组在各种日常活动中的功能损害也有所减少。干预期间未观察到不良事件或安全问题。
多种微量营养素补充剂与CBT相结合在缓解ADHD儿童的神经化学缺陷和行为失调方面显示出潜力。这些发现表明这种综合方法可能有助于管理ADHD症状。
