Zeleke Tirsit Ketsela, Worku Minichil Chanie, Tegegne Bantayehu Addis, Tamene Fasil Bayafers, Geremew Gebremariam Wulie, Wondm Samuel Agegnew, Tefera Aschalew Mulatu, Fitgu Ayelign Eshete, Alemayehu Tekletsadik Tekleslassie, Alemu Muluken Adela, Abebe Rahel Belete, Gubae Kale, Teym Abraham
Department of Pharmacy, College of Health Sciences, Debre Markos University, Debre Markos, Ethiopia.
Department of Pharmaceutical Chemistry, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Drugs Context. 2025 Jul 16;14. doi: 10.7573/dic.2025-2-1. eCollection 2025.
Dispensing prescription-only medications without a valid prescription poses significant public health risks, including inappropriate drug use, adverse drug reactions and medication dependence. Narcotics and psychotropic drugs are particularly vulnerable to misuse. Despite this, limited data exist on the dispensing practices of these medications at community drug retail outlets in Ethiopia. This study aimed to assess the extent and factors of non-prescription dispensing of narcotic and psychotropic medications at community drug retail outlets in Ethiopia.
An observational cross-sectional study was conducted using the simulated client method from June 1, 2023, to September 30, 2023, in Debre Markos town, Ethiopia. Three trained volunteer pharmacy professionals acted as simulated clients. A validated simulated client approach was used to request medications through three different scenarios: symptom-based (depression), direct request by name and request by presenting a medication package.
A total of 109 requests were made by the simulated clients at 38 community drug retail outlets during three rounds of observations. The rates of non-prescription dispensing were 28.9% for depression simulation, 60.5% for direct name requests and 81.6% for package-based requests. A total of nine types of narcotic and psychotropic medications were dispensed without prescription, the most common of which were amitriptyline, followed by tramadol, carbamazepine, pethidine and haloperidol.
This study revealed a high prevalence of non-prescription dispensing of narcotic and psychotropic medications, particularly in response to assertive client requests. Urgent regulatory measures are needed to ensure adherence to prescription-only policies, especially for frequently dispensed drugs such as amitriptyline, tramadol and chlorpromazine.
在没有有效处方的情况下配发仅凭处方销售的药品会带来重大公共卫生风险,包括药物使用不当、药物不良反应和药物依赖。麻醉药品和精神药品尤其容易被滥用。尽管如此,关于埃塞俄比亚社区药品零售网点这些药品的配发情况的数据有限。本研究旨在评估埃塞俄比亚社区药品零售网点麻醉药品和精神药品非处方配发的程度及因素。
2023年6月1日至2023年9月30日,在埃塞俄比亚德布雷马科斯镇采用模拟顾客法进行了一项观察性横断面研究。三名经过培训的志愿药学专业人员充当模拟顾客。采用经过验证的模拟顾客方法,通过三种不同场景请求药品:基于症状(抑郁症)、直呼药名直接请求和出示药品包装请求。
在三轮观察期间,模拟顾客在38个社区药品零售网点共提出了109次请求。抑郁症模拟的非处方配发率为28.9%,直呼药名请求的为60.5%,基于包装请求的为81.6%。共有无处方配发了九种麻醉药品和精神药品,最常见的是阿米替林,其次是曲马多、卡马西平、哌替啶和氟哌啶醇。
本研究显示麻醉药品和精神药品非处方配发的发生率很高,尤其是在应对坚定的顾客请求时。需要采取紧急监管措施,以确保遵守仅凭处方销售的政策,特别是对于阿米替林、曲马多和氯丙嗪等经常配发的药物。