Yu Jing, Yin Longkuan, Li Min, Li Qian, Qin Xiangzhi, Qin Long, Tian Yunhong
Department of Gastrointestinal Surgery, Beijing Anzhen Nanchong Hospital, Capital Medical University & Nanchong Central Hospital, Nanchong, China.
Second Clinical Medical College of North, Sichuan Medical College (University), Nanchong, China.
Discov Oncol. 2025 Jul 22;16(1):1385. doi: 10.1007/s12672-025-03160-4.
Gastric cancer (GC), a widely recognized malignant neoplasm, poses significant treatment challenges. It is essential to pursue additional research to uncover novel therapeutic approaches and predictive methodologies. The phenomenon of disulfidptosis, recently identified as a distinct type of programmed cell death, offers intriguing possibilities for therapeutic applications.
This study performed differential analysis, GO analysis, KEGG, GSEA, and other analyses to investigate the relationship between disulfidptosis-related LncRNAs (DRLs) and TCGA GC data. The analysis included 373 gastric cancer samples and 32 normal gastric tissue samples, obtained from [specify data source, e.g., TCGA, GEO, or in-house cohorts]. Samples were rigorously screened based on [criteria, e.g., histopathological confirmation, RNA quality, or clinical completeness], and transcriptomic data were processed using [specific tools or pipelines] to ensure reproducibility. A new, more accurate predictive model was constructed, identifying potential therapeutic targets, signaling pathways, and sensitive drugs.
A refined prognostic signature associated with disulfidptosis in GC was developed through over 200 Lasso regression and MultiCox calculations. It was discovered that AL359182.1 and AC107021.2 could influence GC prognosis by modulating the MYH10/LIGHT JUNCTION or MYH10/REGULATION OF ACTIN CYTOSKELETON pathways. Notably, AL359182.1, newly identified as linked to GC prognosis, emerges as a potential novel therapeutic target. Furthermore, this study enhanced the accuracy of immunotherapy evaluations and screened for potential sensitive drugs.
Leveraging DRLs and TCGA GC data, this research identified highly precise prognostic signatures consisting of four LncRNAs: PINK1-AS, AC107021.2, AL359182.1, and AC009486.1. The discovery of two new signaling pathways could impact the prognosis of GC. AL359182.1 is proposed as a novel potential therapeutic target. The identified signature also effectively predicts the immunogenicity of GC and facilitates the screening of sensitive drugs. Further experimental validation is suggested to strengthen these conclusions.
胃癌（GC）是一种广为人知的恶性肿瘤，带来了重大的治疗挑战。开展更多研究以发现新的治疗方法和预测方法至关重要。二硫键介导的细胞焦亡现象最近被确定为一种独特的程序性细胞死亡类型，为治疗应用提供了有趣的可能性。
本研究进行了差异分析、基因本体（GO）分析、京都基因与基因组百科全书（KEGG）分析、基因集富集分析（GSEA）等分析，以研究二硫键介导的细胞焦亡相关长链非编码RNA（DRL）与TCGA胃癌数据之间的关系。分析纳入了373例胃癌样本和32例正常胃组织样本，这些样本来自[具体数据源，如TCGA、基因表达综合数据库（GEO）或内部队列]。样本根据[标准，如组织病理学确认、RNA质量或临床完整性]进行严格筛选，转录组数据使用[特定工具或流程]进行处理以确保可重复性。构建了一个新的、更准确的预测模型，确定了潜在的治疗靶点、信号通路和敏感药物。
通过200多次套索回归和多因素Cox计算，开发了一种与胃癌中二硫键介导的细胞焦亡相关的精细预后特征。发现AL359182.1和AC107021.2可通过调节MYH10/轻连接或MYH10/肌动蛋白细胞骨架调节途径影响胃癌预后。值得注意的是，新确定与胃癌预后相关的AL359182.1成为一个潜在的新治疗靶点。此外，本研究提高了免疫治疗评估的准确性并筛选了潜在的敏感药物。
利用DRL和TCGA胃癌数据，本研究确定了由四个长链非编码RNA组成的高精度预后特征：PINK1-AS、AC107021.2、AL359182.1和AC009486.1。两条新信号通路的发现可能影响胃癌预后。AL359182.1被提议作为一个新的潜在治疗靶点。所确定的特征还能有效预测胃癌的免疫原性并有助于筛选敏感药物。建议进一步进行实验验证以强化这些结论。
