Manukyan L, Darbinyan L, Simonyan K, Sargsyan V, Hambardzumyan L
1Sensorimotor Integration Lab, Orbeli Institute of Physiology NAS RA, Yerevan, Armenia.
2Neuroendocrine Relationships Lab, Orbeli Institute of Physiology NAS RA, Yerevan, Armenia.
Georgian Med News. 2025 Apr(361):178-184.
Parkinson's disease (PD) is characterized by progressive dopaminergic neurodegeneration leading to motor deficits, yet effective neuroprotective therapies remain limited. Curcuma longa (turmeric), a traditionally cultivated spice in Southeast Asia, exhibits potent antioxidant properties that may counteract neurodegenerative processes. This study investigated the neuroprotective potential of orally administered turmeric extract (1100 mg/kg) in a rotenone-induced rat model of PD. Rats received rotenone (2.5 mg/kg) for 21 days to induce PD-like pathology, followed by concurrent turmeric treatment. Neuroprotective outcomes were assessed using in vivo electrophysiology and the Cylinder test to evaluate motor function and forelimb use asymmetry. Turmeric extract administration significantly prevented rotenone-induced degenerative changes and motor impairments, indicating preservation of neuronal integrity and function. These findings suggest that turmeric extract mitigates rotenone-induced neurotoxicity, supporting its potential as a therapeutic agent for PD. Further studies are warranted to elucidate the underlying molecular mechanisms and optimize dosing strategies.
帕金森病（PD）的特征是进行性多巴胺能神经变性，导致运动功能障碍，但有效的神经保护疗法仍然有限。姜黄是东南亚传统种植的香料，具有强大的抗氧化特性，可能对抗神经退行性过程。本研究调查了口服姜黄提取物（1100毫克/千克）在鱼藤酮诱导的大鼠帕金森病模型中的神经保护潜力。大鼠接受鱼藤酮（2.5毫克/千克）处理21天以诱导帕金森病样病理，随后同时进行姜黄治疗。使用体内电生理学和圆筒试验评估神经保护结果，以评估运动功能和前肢使用不对称性。给予姜黄提取物可显著预防鱼藤酮诱导的退行性变化和运动障碍，表明神经元完整性和功能得以保留。这些发现表明，姜黄提取物可减轻鱼藤酮诱导的神经毒性，支持其作为帕金森病治疗药物的潜力。有必要进一步研究以阐明潜在的分子机制并优化给药策略。
