Kumar Ashutosh, Kumar Amit, Islam Md Moidul, Borgohain Ranadeep, Raikwar Sarjana
Department of Pharmaceutics, ISF College of Pharmacy, GT Road, Moga, 142001, Punjab, India.
Department of Pharmacy, PCTE Group of Institutes, Ludhiana, Punjab, 142021, India.
Curr Drug Targets. 2025 Jul 21. doi: 10.2174/0113894501371882250713174322.
Urinary tract infections (UTIs) range from mild to severe cases, commonly caused by uropathogenic Escherichia coli (E. coli). The growing concern about antibiotic resistance demands alternative treatment strategies. Nanotechnology, particularly nanocarriers, presents a promising solution by enhancing drug delivery, antibacterial activity, and targeted therapy. This review focuses on the emerging role of combining herbal remedies with nanotechnology for more effective and personalized management of UTIs, aiming to overcome the limitations of conventional antibiotic therapies.
The review involved an extensive search of scientific databases and relevant literature, including studies published to date from PubMed, Science Direct, and Google Scholar. Urinary tract infections (UTI), antibiotic resistance, nanotechnology, drug delivery, targeted drug delivery, and herbal drugs were among the search phrases used.
According to studies, combining herbal extracts such as neem and turmeric with nanotechnology significantly enhances antimicrobial activity against UTI pathogens. These nanoformulations show enhanced bacterial inhibition, reduced inflammation, and increased therapeutic precision with minimal side effects.
The synergistic use of herbal remedies and nanocarriers offers a novel approach to managing UTIs. Nanotechnology not only enhances drug delivery but also improves diagnostic accuracy through fluorescence markers and biomolecule tagging. This strategy effectively addresses growing antibiotic resistance and supports the development of personalized treatments. The combination of natural bioactives and advanced delivery systems offers a safer, more effective alternative to conventional antibiotics in treating UTIs.
The integration of nanotechnology and herbal therapies revolutionizes UTI management through precision medicine. This approach enhances treatment efficacy, diagnostic accuracy, and patient outcomes, offering a personalized solution to combat antibiotic resistance and urinary tract abnormalities with improved targeting and minimal side effects.
尿路感染(UTIs)病情轻重不一,通常由尿路致病性大肠杆菌(E. coli)引起。对抗生素耐药性的日益关注促使人们寻求替代治疗策略。纳米技术,尤其是纳米载体,通过增强药物递送、抗菌活性和靶向治疗,提供了一个有前景的解决方案。本综述聚焦于将草药疗法与纳米技术相结合在更有效和个性化管理尿路感染方面的新兴作用,旨在克服传统抗生素疗法的局限性。
本综述广泛检索了科学数据库和相关文献,包括来自PubMed、Science Direct和谷歌学术的迄今已发表的研究。检索词包括尿路感染(UTI)、抗生素耐药性、纳米技术、药物递送、靶向药物递送和草药。
根据研究,将印楝和姜黄等草药提取物与纳米技术相结合可显著增强对尿路感染病原体的抗菌活性。这些纳米制剂显示出增强的细菌抑制作用、减轻的炎症反应以及更高的治疗精准度,且副作用最小。
草药疗法与纳米载体的协同使用为管理尿路感染提供了一种新方法。纳米技术不仅增强了药物递送,还通过荧光标记和生物分子标记提高了诊断准确性。这种策略有效应对了日益增长的抗生素耐药性,并支持个性化治疗的发展。天然生物活性物质与先进递送系统的结合为治疗尿路感染提供了一种比传统抗生素更安全、更有效的替代方案。
纳米技术与草药疗法的整合通过精准医学彻底改变了尿路感染的管理。这种方法提高了治疗效果、诊断准确性和患者预后,提供了一种个性化解决方案,以对抗抗生素耐药性和尿路异常,具有更好的靶向性和最小的副作用。