右美托咪定在癌症患者围手术期疼痛管理中的免疫调节潜力。
Immunomodulatory potential of dexmedetomidine in perioperative pain management for patients with cancer.
作者信息
Liu Yuxian, Ma He, Wang Xintong, Yang Isabelle, Wang Jingping
机构信息
Phillips Academy, Andover, MA 01810, USA.
Department of Anesthesia, The Second Hospital of Jilin University, Changchun, Jilin 130021 China.
出版信息
Cancer Pathog Ther. 2025 Jan 2;3(4):353-356. doi: 10.1016/j.cpt.2024.12.007. eCollection 2025 Jul.
•Dexmedetomidine (DEX) has immunomodulatory effects in perioperative pain management.•DEX can reduce pro-inflammatory cytokines.•DEX has dose-dependent effects on tumor progression.•Optimizing DEX dosing may improve the therapeutic outcomes of cancer surgery.•Further research is needed to clarify DEX's impact on cancer recurrence and survival, as the findings remain mixed.
•右美托咪定（DEX）在围手术期疼痛管理中具有免疫调节作用。
•DEX可降低促炎细胞因子水平。
•DEX对肿瘤进展具有剂量依赖性影响。
•优化DEX给药剂量可能改善癌症手术的治疗效果。
•由于研究结果不一，需要进一步研究以阐明DEX对癌症复发和生存的影响。
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