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术后近距离放射疗法治疗瘢痕疙瘩:一项单中心研究。

Post-surgical brachytherapy in the treatment of keloids: A single-center study.

作者信息

Gonzalez-Alaña Irene, Martin-Playa Patricia, Aparicio-Elizalde Leire, Yilmaz-Bescos Unay, Casquero-Ocio Francisco, Valverde-Pascual Itziar, Perez-Fernandez Silvia, Carames-Estefania Jaime, Miguel-Arregui Iñigo San

机构信息

Cruces University Hospital, Barakaldo, Spain.

Salamanca University Care Complex, Spain.

出版信息

J Contemp Brachytherapy. 2025 Jun;17(3):153-159. doi: 10.5114/jcb.2025.151825. Epub 2025 Jun 4.

Abstract

PURPOSE

A keloid is a benign fibro-dermal tumor that produces an excess deposit of extra-cellular matrix. It usually occurs after a skin lesion, and it spreads beyond the wound. It is characterized by high recurrence rate after excision and lack of tendency of spontaneous involution. Multiple treatments have been described, with recurrence rates of up to 100%. One of the treatments considered most effective is combined therapy, i.e., surgery and subsequent radiotherapy using interstitial irradiation with iridium-192 (brachytherapy), with a clear reduction in recurrence rate.

MATERIAL AND METHODS

In our center, the technique was introduced in 2012, and the current retrospective observational study was conducted among 27 patients treated till December 2020.

RESULTS

The recurrence rate in the study was 25%, of which 83% recurred partially.

CONCLUSIONS

The most frequent complications observed were dehiscence and infection of the surgical wound, therefore this therapeutic approach can be considered both safe and effective.

摘要

目的

瘢痕疙瘩是一种良性纤维-真皮肿瘤,会产生细胞外基质的过量沉积。它通常在皮肤损伤后出现,并超出伤口范围扩散。其特点是切除后复发率高且无自发消退倾向。已有多种治疗方法被描述,复发率高达100%。被认为最有效的治疗方法之一是联合治疗,即手术及随后使用铱-192进行组织间照射的放射治疗(近距离放疗),复发率明显降低。

材料与方法

在我们中心,该技术于2012年引入,对截至2020年12月接受治疗的27例患者进行了本次回顾性观察研究。

结果

该研究中的复发率为25%,其中83%为部分复发。

结论

观察到的最常见并发症是手术伤口裂开和感染,因此这种治疗方法可被认为既安全又有效。

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