Zhang Mingdong, Zhao E, Sun Gaofeng
School of Public Health, Xinjiang Medical University, Urumqi, China.
Department of Chronic Non-Communicable Disease Prevention and Control, Urumqi Center for Disease Control and Prevention, Urumqi Municipal Health Supervision Institute, Urumqi, China.
Front Public Health. 2025 Jul 8;13:1620261. doi: 10.3389/fpubh.2025.1620261. eCollection 2025.
This study aims to explore the correlation between waist circumference and the prevalence of fatty liver disease in the older adult population in Urumqi.
Through cluster random sampling of healthcare institutions within the urban districts of Urumqi, a final cohort of 3,907 participants was enrolled from three institutions. In addition, the informed consent forms of the participants were obtained. Chi-square tests were used for univariate analysis between groups, and the data were divided into a training set and a test set in a 7:3 ratio. Variables were further screened using machine learning models such as random forest classifier and Lasso. Logistic regression and restricted cubic spline models were used to analyze the correlation between waist circumference and fatty liver disease.
The prevalence of fatty liver disease was 32.56%, with 31.54% in men and 33.40% in women. Multivariate logistic regression analysis showed that compared with non-central obesity, the risk of fatty liver disease in central obesity was significantly higher ( = 1.768, 95% : 1.481-2.112). The restricted cubic spline model analysis showed that the risk of fatty liver disease increased with waist circumference in the older adult population. In the total population and the male group, waist circumference and central obesity showed a nonlinear relationship, while in the female group, those below 75 years old, and those 75 and older, a linear relationship was observed.
Controlling waist circumference is important for the prevention of fatty liver disease. The older adult population in Urumqi should pay attention to the risks posed by increasing waist circumference.
本研究旨在探讨乌鲁木齐市老年人群腰围与脂肪肝患病率之间的相关性。
通过对乌鲁木齐市区医疗机构进行整群随机抽样，最终从三家机构招募了3907名参与者。此外，获取了参与者的知情同意书。采用卡方检验进行组间单因素分析，并将数据按7:3的比例分为训练集和测试集。使用随机森林分类器和套索等机器学习模型进一步筛选变量。采用逻辑回归和受限立方样条模型分析腰围与脂肪肝之间的相关性。
脂肪肝患病率为32.56%，男性为31.54%，女性为33.40%。多因素逻辑回归分析显示，与非中心性肥胖相比，中心性肥胖人群患脂肪肝的风险显著更高（β = 1.768，95%CI：1.481 - 2.112）。受限立方样条模型分析表明，老年人群中脂肪肝的风险随腰围增加而升高。在总人群和男性组中，腰围与中心性肥胖呈非线性关系，而在女性组、75岁以下女性组和75岁及以上女性组中，呈线性关系。
控制腰围对预防脂肪肝很重要。乌鲁木齐市老年人群应注意腰围增加带来的风险。
