Maciejewska Karina J
Institute of Biomedical Engineering, Faculty of Science and Technology, University of Silesia in Katowice, Katowice, Poland.
Front Neuroinform. 2025 Jul 8;19:1563893. doi: 10.3389/fninf.2025.1563893. eCollection 2025.
This paper describes an experimental work using machine learning (ML) as a "decoding for interpretation" to understand the brain's physiology better.
Multivariate pattern analysis (MVPA) was used to decode the patterns of event-related potentials (ERPs, brain responses to stimuli) in a visual oddball task. The ERPs were measured before (run 1) and after (30 min-run 2, 90 min-run 3) a single dose of an energy dietary supplement with only a small amount of caffeine.
Its effect on ERPs was successfully decoded. Above-chance decoding accuracies were obtained between ∼350 and 450 ms (corresponds to P3 peak) after stimulus onset for both the placebo and study groups, whereas between ∼200 and 260 ms (corresponds to P2 waveform) only in the placebo group. Moreover, the decoding accuracies were significantly higher in the placebo than in the study group in the 200-250 ms and 450-500 ms time bins. Our previously reported findings showed an increase in P3 amplitude among the runs only in the placebo group, indicating a reduction of mental fatigue caused by the supplementation.
Thus, this paper extends these results, showing that the dietary supplement affected the brain's neural activity related to the attention-related processing of the visual stimuli in the oddball task already at the early processing stage. This implies that inhibiting the fatigue-related brain changes after only a single dose of a dietary neurostimulant acts on early and late processing stages. This emphasizes the value of decoding for interpretation in ERP research. The results also point out the necessity of controlling the uptake of dietary supplements before the neurophysiological examinations.
本文描述了一项实验工作，该工作使用机器学习（ML）作为“解码以进行解读”，以便更好地理解大脑的生理学。
在视觉Oddball任务中，使用多变量模式分析（MVPA）对事件相关电位（ERP，大脑对刺激的反应）模式进行解码。在服用仅含有少量咖啡因的能量膳食补充剂单剂量之前（运行1）和之后（30分钟 - 运行2，90分钟 - 运行3）测量ERP。
成功解码了其对ERP的影响。安慰剂组和研究组在刺激开始后约350至450毫秒（对应于P3峰值）之间均获得了高于机会水平的解码准确率，而仅在安慰剂组中在约200至260毫秒（对应于P2波形）之间获得了高于机会水平的解码准确率。此外，在200 - 250毫秒和450 - 500毫秒时间区间内，安慰剂组的解码准确率显著高于研究组。我们之前报道的研究结果表明，仅在安慰剂组中各次运行之间P3波幅有所增加，表明补充剂减轻了精神疲劳。
因此，本文扩展了这些结果，表明该膳食补充剂在早期处理阶段就已经影响了大脑与Oddball任务中视觉刺激的注意力相关处理相关的神经活动。这意味着仅服用一剂膳食神经兴奋剂后抑制与疲劳相关的大脑变化作用于早期和晚期处理阶段。这强调了解码在ERP研究中用于解读的价值。结果还指出了在神经生理学检查之前控制膳食补充剂摄入的必要性。
