Huang Jingtao, Jia Shicheng, Liang Rongji, Li Aikang, Li Lin, Wang Haojian, Chen Jiayou, Tang Haoxian, Zhang Xuan, Lin Jianjing, Zhang Xintao
Department of Sports Medicine and Rehabilitation, Peking University Shenzhen Hospital, Shenzhen, 518036, China.
Department of Clinical Medicine, Shantou University Medical College, Shantou, Guangdong, 515041, China.
J Orthop Translat. 2025 Jul 16;54:37-50. doi: 10.1016/j.jot.2025.06.020. eCollection 2025 Sep.
Articular cartilage defects caused by trauma or degeneration severely impair patient function. Cartilage repair organoids represent a transformative approach in regenerative medicine to address these challenges. This review focuses on the development and therapeutic potential of such organoids, detailing their role in overcoming limitations of conventional treatments. Central to this progress, bioprinting technology enables precise organoid fabrication by advancing organoid-compatible bioinks and printing techniques. We further examine applications in disease modeling and drug screening, alongside pathways for clinical translation. As organoid engineering matures, it promises to deliver effective, patient-specific solutions for cartilage restoration. The Translational Potential Statement: The Translational Potential of this Article: 3D-bioprinted cartilage organoids exhibit outstanding efficacy in animal models and hold promise for future clinical trials. The bioinks and printing technologies are distilled to promote basic research toward translation of cartilage repair.
创伤或退变引起的关节软骨缺损会严重损害患者功能。软骨修复类器官是再生医学中应对这些挑战的一种变革性方法。本综述聚焦于此类类器官的发展及治疗潜力，详细阐述它们在克服传统治疗局限性方面的作用。这一进展的核心是，生物打印技术通过改进与类器官兼容的生物墨水和打印技术，实现了类器官的精确制造。我们还研究了其在疾病建模和药物筛选中的应用，以及临床转化途径。随着类器官工程的成熟，它有望为软骨修复提供有效、针对患者的解决方案。转化潜力声明：本文的转化潜力：3D生物打印软骨类器官在动物模型中显示出卓越疗效，有望用于未来的临床试验。对生物墨水和打印技术进行了提炼，以推动软骨修复转化的基础研究。
