Lee Jeongmin, Yeo Seung Geun, Lee Jae Min, Kim Sung Soo, Lee Jin-Woo, Chung Namhyun, Park Dong Choon
Department of Medicine, College of Medicine, Kyung Hee University Medical Center, Seoul 02447, Republic of Korea.
Department of Otorhinolaryngology Head & Neck Surgery, College of Medicine, Kyung Hee University Medical Center, Seoul 02447, Republic of Korea.
Antioxidants (Basel). 2025 Jul 17;14(7):877. doi: 10.3390/antiox14070877.
This review explores the dual role of reactive oxygen species (ROS) and free radicals in the pathogenesis of endometriosis, aiming to deepen our understanding of these processes through a systematic literature review. To assess the induction and involvement of ROS in endometriosis, we conducted a comprehensive literature review using Cochrane Libraries, EMBASE, Google Scholar, PubMed, and SCOPUS databases. Of 30 qualifying papers ultimately reviewed, 28 reported a significant contribution of ROS to the pathogenesis of endometriosis, while two found no association. The presence of ROS in endometriosis is associated with infertility, irregular menstrual cycles, painful menstruation, and chronic pelvic discomfort. Among individual ROS types studied, hydrogen peroxide was most frequently investigated, followed by lipid peroxides and superoxide radicals. Notable polymorphisms associated with ROS in endometriosis include those for AT-rich interactive domain 1A (ARID1A) and quinone oxidoreductase 1 (NQO1) isoforms. Key enzymes for ROS scavenging and detoxification include superoxide dismutase, glutathione, and glutathione peroxidase. Effective inhibitors of ROS related to endometriosis are vitamins C and E, astaxanthin, fatty acid-binding protein 4, cerium oxide nanoparticles (nanoceria), osteopontin, sphingosine 1-phosphate, N-acetyl-L-cysteine, catalase, and a high-antioxidant diet. Elevated levels of ROS and free radicals are involved in the pathogenesis of endometriosis, suggesting that targeting these molecules could offer potential therapeutic strategies.
本综述探讨了活性氧（ROS）和自由基在子宫内膜异位症发病机制中的双重作用，旨在通过系统的文献综述加深我们对这些过程的理解。为了评估ROS在子宫内膜异位症中的诱导和参与情况，我们使用Cochrane图书馆、EMBASE、谷歌学术、PubMed和SCOPUS数据库进行了全面的文献综述。在最终审查的30篇合格论文中，28篇报告ROS对子宫内膜异位症的发病机制有显著贡献，而两篇未发现关联。子宫内膜异位症中ROS的存在与不孕、月经周期不规律、痛经和慢性盆腔不适有关。在研究的个体ROS类型中，过氧化氢研究最为频繁，其次是脂质过氧化物和超氧自由基。与子宫内膜异位症中ROS相关的显著多态性包括富含AT的交互结构域1A（ARID1A）和醌氧化还原酶1（NQO1）同工型的多态性。ROS清除和解毒的关键酶包括超氧化物歧化酶、谷胱甘肽和谷胱甘肽过氧化物酶。与子宫内膜异位症相关的ROS有效抑制剂包括维生素C和E、虾青素、脂肪酸结合蛋白4、氧化铈纳米颗粒（纳米铈）、骨桥蛋白、鞘氨醇1-磷酸、N-乙酰-L-半胱氨酸、过氧化氢酶和高抗氧化饮食。ROS和自由基水平升高参与了子宫内膜异位症的发病机制，这表明针对这些分子可能提供潜在的治疗策略。
