OBJECTIVES: Patients with Parkinson's disease (PD) highly complain of pain, probably due to the lowered pain threshold caused by dopamine deficiency. Nonetheless, only a few studies have investigated the effects of anti-PD medications on "pain inhibits pain" ability. This study aimed to evaluate conditioned pain modulation (CPM) using the cutaneous silent period (CSP) and the numerical rating scale (NRS) and to investigate the effect of anti-PD medications on CPM. MATERIALS AND METHODS: The CSP was recorded in 40 patients with PD under drug-on and drug-off conditions. Changes in the CSP elicited by electrical test stimulation and in the NRS when the patients experienced pain with cold pressure as a conditioned stimulus were assessed. A shortened CSP duration or reduced CSP score due to cold pressure were interpreted as objective CPM responses. RESULTS: The CSP latency was analyzed in 22 patients when the electromyographic contamination in the CSP waveform was low. The CSP duration shortening during cold pressure was significantly greater under the drug-on condition than under the drug-off condition. The change in CSP duration exhibited a significant correlation with the change in the NRS scores. CSP score analysis was performed on 18 patients in whom latency analysis was difficult owing to electromyographic contamination. In the drug-on state, conditioned cold-pressure pain significantly decreased the CSP score. CONCLUSIONS: Dynamic changes in the CSP caused by cold pressure in patients with PD suggest that anti-PD medications may enhance CPM ability.