Smith Lee, López Sánchez Guillermo F, Veronese Nicola, Soysal Pinar, Tully Mark A, Kostev Karel, Butler Laurie, Keyes Helen, Barnett Yvonne, Shin Jae Il, Koyanagi Ai
Centre for Health Performance and Wellbeing, Anglia Ruskin University, Cambridge, UK.
Department of Public Health, Faculty of Medicine, Biruni University, Istanbul, Turkey.
Commun Med (Lond). 2025 Jul 29;5(1):315. doi: 10.1038/s43856-025-01037-9.
As far as we are aware, to date, there are no studies on the association between dynapenic abdominal obesity (DAO) and physical multimorbidity (i.e., ≥2 chronic conditions). Thus, we aimed to examine this association among older adults from six low- and middle-income countries (LMICs).
Cross-sectional, nationally representative data from the Study on Global Ageing and Adult Health were analyzed. Data on 20,198 adults aged ≥60 years were analyzed [mean (SD) age 69.4 (13.1) years; 54.1% females]. Information on 11 chronic physical conditions was obtained. Dynapenia was defined as <26 kg for men and <16 kg for women. Abdominal obesity was defined as waist circumference of >88 cm for women and >102 cm for men. DAO was defined as having both dynapenia and abdominal obesity. Multivariable logistic regression was conducted.
After adjustment for potential confounders, compared to no dynapenia and no abdominal obesity, dynapenia alone, abdominal obesity alone, and DAO are associated with 1.34 (95% CI = 1.16-1.55), 1.64 (95% CI = 1.36-1.98), and 2.49 (95% CI = 1.94-3.19) times higher odds for physical multimorbidity, respectively.
Dynapenic abdominal obesity is significantly associated with higher odds for physical multimorbidity among older adults in LMICs. Prevention and management of dynapenic abdominal obesity may aid in reducing the burden of physical multimorbidity, pending future longitudinal research.
据我们所知，迄今为止，尚无关于肌无力性腹型肥胖（DAO）与身体多种疾病（即≥2种慢性病）之间关联的研究。因此，我们旨在研究六个低收入和中等收入国家（LMICs）的老年人中的这种关联。
分析了来自全球老龄化与成人健康研究的横断面、具有全国代表性的数据。分析了20198名年龄≥60岁的成年人的数据[平均（标准差）年龄为69.4（13.1）岁；女性占54.1%]。获取了11种慢性身体疾病的信息。肌无力定义为男性<26千克，女性<16千克。腹型肥胖定义为女性腰围>88厘米，男性腰围>102厘米。DAO定义为同时存在肌无力和腹型肥胖。进行了多变量逻辑回归分析。
在对潜在混杂因素进行调整后，与无肌无力且无腹型肥胖相比，单独的肌无力、单独的腹型肥胖和DAO与身体多种疾病的患病几率分别高出1.34倍（95%置信区间=1.16-1.55）、1.64倍（95%置信区间=1.36-1.98）和2.49倍（95%置信区间=1.94-3.19）。
在低收入和中等收入国家的老年人中，肌无力性腹型肥胖与身体多种疾病的较高患病几率显著相关。在未来的纵向研究之前，预防和管理肌无力性腹型肥胖可能有助于减轻身体多种疾病的负担。
