Hargis A M, Prieur D J
Am J Med Genet. 1985 Dec;22(4):659-68. doi: 10.1002/ajmg.1320220403.
Cats with a condition resembling human Chediak-Higashi syndrome (CHS) are the most recently described of five species of animals with similar syndromes. In this study, hepatocytes of cats with CHS were examined by light microscopy, histochemistry, and transmission electron microscopy. Enlarged cytoplasmic granules, morphologically consistent with lysosomes, were present in many of the CHS cat hepatocytes. The enlarged lysosomes were generally larger and more numerous in centrilobular hepatocytes and were generally larger in older cats. The lesions were similar to those reported in other species with CHS suggesting that CHS cats are a valid animal model of human CHS.
患有类似人类切-希二氏综合征（CHS）病症的猫，是最近被描述的患有类似综合征的五种动物之一。在本研究中，通过光学显微镜、组织化学和透射电子显微镜对患有CHS的猫的肝细胞进行了检查。许多患有CHS的猫肝细胞中存在形态上与溶酶体一致的扩大的细胞质颗粒。扩大的溶酶体在小叶中央肝细胞中通常更大且数量更多，并且在老年猫中通常更大。这些病变与其他患有CHS的物种中报道的病变相似，这表明患有CHS的猫是人类CHS的有效动物模型。
