Benanti Giovanni, Ramirez Giuseppe A, Schioppo Tommaso, Argolini Lorenza Maria, Moroni Gabriella, Bonelli Grazia, Sinico Renato Alberto, Alberici Federico, Mescia Federica, Moroni Luca, Gallina Gabriele D, Venerandi Biancamaria, Tamborini Francesco, Bellocchi Chiara, Beretta Lorenzo, Caporali Roberto, Bozzolo Enrica, Dagna Lorenzo, Gerosa Maria
Unit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS Ospedale San Raffaele, 20132 Milan, Italy.
Unit of General Medicine and Advanced Care, IRCCS Ospedale San Raffaele, 20132 Milan, Italy.
Vaccines (Basel). 2025 Jul 8;13(7):735. doi: 10.3390/vaccines13070735.
: Systemic lupus erythematosus (SLE) is associated with infection-related morbidity. The risk of adverse outcomes secondary to infections was exacerbated during the recent COVID-19 pandemic, prompting mass vaccination with the novel mRNA-based and viral-vectored vaccines. Limited data exist on the long-term impact of vaccination in patients with SLE. : A post-vaccine group (PVG, = 284) from a multicentric cohort of vaccinated patients with SLE from six tertiary referral centres in Northen Italy was compared with a control group (CG, = 223) of similar demographics observed in the 2015-2019 period to investigate survival, hospitalisation, pregnancy, disease flare, disease progression, infection, and chronic complication accrual rates. : We did not observe excess SLE flares, SLE progression, hospitalisation, or pregnancy complications in the PVG. Cardiovascular complications due to comorbidities or to SLE were lower in the PVG than in the CG. Infections were more frequent in the PVG, related to COVID-19 in half of the cases, and were associated with SLE flares. : Taken together, these data indicate that anti-COVID-19 vaccines are safe in the long-term when administered to patients with SLE. Stable, non-null rates of chronic comorbidity accrual and hospitalisation point out the existence of persistently unmet needs in patients with SLE.
系统性红斑狼疮（SLE）与感染相关的发病率有关。在最近的新冠疫情期间，感染继发不良后果的风险加剧，这促使人们大规模接种新型mRNA疫苗和病毒载体疫苗。关于疫苗接种对SLE患者的长期影响的数据有限。：将来自意大利北部六个三级转诊中心的多中心接种SLE患者队列中的疫苗接种后组（PVG，n = 284）与2015 - 2019年期间观察到的具有相似人口统计学特征的对照组（CG，n = 223）进行比较，以研究生存率、住院率、妊娠情况、疾病发作、疾病进展、感染和慢性并发症累积率。：我们在PVG中未观察到SLE发作、SLE进展、住院或妊娠并发症过多的情况。PVG中因合并症或SLE导致的心血管并发症低于CG。PVG中的感染更频繁，其中一半病例与新冠病毒有关，且与SLE发作相关。：综上所述，这些数据表明，抗新冠病毒疫苗长期应用于SLE患者是安全的。慢性合并症累积率和住院率稳定且不为零，这表明SLE患者仍存在持续未满足的需求。
